Evidence map›Paper›PMID 40040711›Full record

ArticleFrontiers in immunology2025

Vitamin K supports TGF-β1 depended

Thomas Bauer, Susanne Richter-Eder, Nighat Yasmin, Jennifer Jurkin, René Köffel, Herbert Strobl

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas BauerCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Susanne Richter-EderInstitute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Nighat YasminInstitute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Jennifer JurkinInstitute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
René KöffelInstitute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Herbert StroblDivision of Immunology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: On the outermost edge of the body a dense network of dendritic cells (DCs), the so-called Langerhans cells (LCs), represents the first immune barrier. The establishment and maintenance of this epidermal network is dependent on the cytokine transforming growth factor-β1 (TGF-β1) expressed by keratinocytes (KC) and LCs. We recently identified a crucial downstream effector of TGF-β1, the receptor tyrosine kinase Axl. Axl belongs to the TAM receptor family, which also includes Tyro3 and Mer, and is activated through the vitamin K-dependent ligands Gas6 and Protein S. Methods: We have now established that TGF-β1 dependent Results: Additionally, we supplemented vitamin K into serum-free human LC generation cultures in order to activate the endogenous ligands Gas6 and Protein S. Vitamin K exhibited supportive effects on LC differentiation and LC-associated gene expression. The vitamin K antagonist warfarin on the other hand, hindered efficient LC differentiation. Blocking antibodies against Axl abrogated the positive effect of vitamin K on LC differentiation. Lastly, vitamin K downregulated the immune activation marker CD86 during LC differentiation and blocked the upregulation of CD86 during LC activation Discussion: Taken together, we provide evidence for the supportive role of vitamin K in regulating skin immunity.

Indexed as

Cell DifferentiationLangerhans CellsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesTransforming Growth Factor beta1Vitamin KAxl Receptor Tyrosine KinaseCells, CulturedGrowth Arrest-Specific Protein 6HumansIntercellular Signaling Peptides and ProteinsKeratinocytesProtein SAXL protein, humanAxl Receptor Tyrosine KinaseGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and ProteinsProtein SProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesTGFB1 protein, humanTransforming Growth Factor beta1Vitamin Kdendritic cellkeratinocyteLangerhans cellreceptor tyrosine kinase Axltransforming growth factor

Identifiers

PMID40040711
PMCPMC11876179

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