Evidence map›Paper›PMID 40040648›Full record

ArticleHealth affairs scholar2025

Trends in antipsychotic prescribing among community-dwelling older adults with dementia, 2010-2018.

Annie W Yang, Mei Leng, Julia Cave Arbanas, Chi-Hong Tseng, A Mark Fendrick, Catherine Sarkisian, Cheryl L Damberg, Nina T Harawa, John N Mafi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health affairs scholar, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annie W YangDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.ORCID https://orcid.org/0000-0001-5368-1514
Mei LengDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.
Julia Cave ArbanasDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.
Chi-Hong TsengDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.ORCID https://orcid.org/0000-0002-2549-6167
A Mark FendrickInternal Medicine, Health Management and Policy, University of Michigan, Ann Arbor, MI 48109, USA.
Catherine SarkisianDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.ORCID https://orcid.org/0000-0003-2768-2323
Cheryl L DambergRAND Health, RAND Corporation, Santa Monica, CA 90401, USA.
Nina T HarawaDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.ORCID https://orcid.org/0000-0002-7486-8393
John N MafiDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.

Funding

UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Identifying Approaches to Measure and Reduce Harmful, Low-Value Care Among Older Americans with Mild Cognitive Impairment and DementiaR01AG070017 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAFI, JOHN N. · 2021 to 2025
$2.6M
Midcareer Award in Patient-Oriented Community-Academic Partnered Aging ResearchK24AG047899 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SARKISIAN, CATHERINE A · 2014 to 2025
$2.0M
Leveraging Electronic Health Records to Measure and Reduce Harmful, Low-Value Care Among Older AdultsK76AG064392 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAFI, JOHN · 2020 to 2024
$1.2M
NCRR NIH HHS UL1 RR033176NIA NIH HHS K24 AG047899NIA NIH HHS K76 AG064392NIA NIH HHS R01 AG070017
6 · The paper itself

Abstract

Due to an FDA "black box" warning for heightened risk of death, Choosing Wisely (CW) recommends avoiding antipsychotic prescription drugs as first-line treatment for dementia-related agitation. Yet, post-CW trends among community-dwelling patients with dementia remain unknown. In this retrospective cohort study, we used nationally representative Health and Retirement Study survey data linked to Medicare fee-for-service claims (January 1, 2010-December 31, 2018) to analyze prescribing trends during the pre-publication (2010-2012), publication (2013-2015), and post-publication (2016-2018) periods of CW recommendations. We included community-dwelling adults aged ≥65 years with dementia. We utilized multivariable mixed regression models to determine the percentage of patients prescribed any, potentially low-value, and potentially indicated antipsychotics. Among an estimated 2.4-2.7 million patients with dementia, any antipsychotic prescribing increased from 9.4% (95% CI, 6.4%-12.3%) during the pre-publication period (2010-2012) to 15.8% (95% CI, 12.8%-18.8%) (

Indexed as

antipsychoticsdementialow-value careolder adultsquality of care

Identifiers

PMID40040648
PMCPMC11878382

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.