Evidence map›Paper›PMID 40040444›Full record

ArticleJournal of agricultural and food chemistry2025

Mechanistic Insights into the Membrane Permeabilization Activity of Antimicrobial Prenylated Isoflavonoids: A Comparative Study of Glabridin, Wighteone, and Lupiwighteone.

Alberto Bombelli, Paolo Calligari, Gianfranco Bocchinfuso, Jean-Paul Vincken, Tjakko Abee, Heidy M W den Besten, Lorenzo Stella, Carla Araya-Cloutier

Abstract readComparative Study
In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Polyphenolic compounds inFrontiers in pharmacology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alberto BombelliFood Microbiology, Wageningen University & Research, AA Wageningen 6700, the Netherlands.ORCID 0000-0003-0669-2928
Paolo CalligariDepartment of Chemical Science and Technologies, Tor Vergata University of Rome, Rome 00133, Italy.
Gianfranco BocchinfusoDepartment of Chemical Science and Technologies, Tor Vergata University of Rome, Rome 00133, Italy.ORCID 0000-0002-5556-7691
Jean-Paul VinckenFood Chemistry, Wageningen University & Research, AA Wageningen 6700, the Netherlands.ORCID 0000-0001-8540-4327
Tjakko AbeeFood Microbiology, Wageningen University & Research, AA Wageningen 6700, the Netherlands.
Heidy M W den BestenFood Microbiology, Wageningen University & Research, AA Wageningen 6700, the Netherlands.
Lorenzo StellaDepartment of Chemical Science and Technologies, Tor Vergata University of Rome, Rome 00133, Italy.ORCID 0000-0002-5489-7381
Carla Araya-CloutierFood Chemistry, Wageningen University & Research, AA Wageningen 6700, the Netherlands.ORCID 0000-0002-9304-4971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenylated isoflavonoids have shown remarkable antimicrobial activity. Previous studies showed that the antimicrobial compounds glabridin and wighteone induced membrane permeabilization in microbial cells. Other compounds, such as lupiwighteone, showed no antimicrobial activity. In this study, the permeabilization efficacy and interaction with lipid bilayers of glabridin, wighteone, and lupiwighteone were assessed

Indexed as

Anti-Infective AgentsIsoflavonesPhenolsCell MembraneCell Membrane PermeabilityLipid BilayersLiposomesMolecular Dynamics SimulationPermeabilityPrenylationAnti-Infective AgentsglabridinIsoflavonesLipid BilayersLiposomesPhenolsliposomesmode of actionmolecular dynamicsphospholipidsimulation

Identifiers

PMID40040444
PMCPMC11926876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.