Evidence map›Paper›PMID 40040357›Full record

ArticleEuropean journal of neurology2025

Free Water as a Marker of Early Small Vessel Disease in Healthy Aging.

Manuel Leitner, Lukas Pirpamer, Edith Hofer, Stefan Ropele, Ofer Pasternak, Reinhold Schmidt, Marisa Koini

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manuel LeitnerDepartment of Neurology, Medical University of Graz, Graz, Austria.ORCID 0000-0001-5267-1103
Lukas PirpamerDepartment of Neurology, Medical University of Graz, Graz, Austria.
Edith HoferDepartment of Neurology, Medical University of Graz, Graz, Austria.
Stefan RopeleDepartment of Neurology, Medical University of Graz, Graz, Austria.
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Reinhold SchmidtDepartment of Neurology, Medical University of Graz, Graz, Austria.
Marisa KoiniDepartment of Neurology, Medical University of Graz, Graz, Austria.

Funding

Austrian Science Fund FWF I2889-B31Deutsche Forschungsgemeinschaft DFG DU1626/1-1
6 · The paper itself

Abstract

backgroundBrain aging is associated with cerebrovascular changes and related microstructural pathology. In this context, research indicates that small vessel disease (SVD) is characterized by increases in extracellular free water (FW).

methodsWe examined 94 individuals with early signs of small vessel disease (eSVD; M

resultsDifferences between individuals with eSVD and CON were identified for FW in NAWM and FW-uncorrected DTI, but not for FW-corrected DTI measures. Both FW and FW-uncorrected DTI measures in NAWM were significantly associated with age across the total sample (r

conclusionsEven in subjects with subtle, clinically silent, cerebral white matter changes, increases in FW could be observed compared to individuals without those changes. Therefore, FW might act as a sensitive marker at the earliest signs of SVD.

Indexed as

AgingBrainCerebral Small Vessel DiseasesHealthy AgingWhite MatterAgedAged, 80 and overBiomarkersDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedBiomarkersdiffusion tensor imagingfree waterhealthy agingmarkersmall vessel disease

Identifiers

PMID40040357
PMCPMC11880618

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