SynthesisEuropean journal of neurology2025
Comorbidities as risk factors for migraine onset: A systematic review and three-level meta-analysis.
Synthesis in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis.Frontiers in medicine · 2026Pooled it
- Risk factors associated to disability in primary headaches: a systematic review to inform future iterations of the Global Burden of Disease Study.The journal of headache and pain · 2025Pooled it
- Systematic review of late-onset aura related to migraine: an overlooked phenomenon.Acta neurologica Belgica · 2025Pooled it
- Bridging the gap between evidence and clinical practice for migraine headaches: a systematic review (2019-2024).The journal of headache and pain · 2025Pooled it
- Comorbidities as risk factors for migraine onset: A systematic review and three-level meta-analysis.European journal of neurology · 2025Pooled it
- Oral preventive medications for migraine in adults aged 18-65: a network meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Review
- Comorbidity of Temporomandibular Disorders, Anxiety, Depression, and Poor Sleep Quality in Episodic and Chronic Migraine: A Cross-Sectional Observational Study.Journal of clinical medicine · 2026Article
- Decoding the lipid-migraine link: a genetic and lipidomic investigation of migraine subtypes.Journal of oral & facial pain and headache · 2026Article
- Associations between temporomandibular disorders/bruxism and head and neck pains: a bidirectional Mendelian randomization study.Journal of oral & facial pain and headache · 2025Article
- Impact of Erenumab on Comorbid Depression, Anxiety, and Sleep Quality in Migraine: A Registry for Migraine (REFORM) Study.European journal of neurology · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Metabolic Dysfunction and Dietary Interventions in Migraine Management: The Role of Insulin Resistance and Neuroinflammation-A Narrative and Scoping Review.Brain sciences · 2025Review
- Association between seasons with substantial atmospheric pressure change and migraine occurrence: a retrospective cohort study using Japanese claims data and meteorological data.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMigraine is a debilitating neurological disease with a multifaceted pathophysiology. Pre-existing comorbidities may influence the risk of developing migraine. This review and meta-analysis aim to present a comprehensive overview of the known comorbidities predisposing individuals to new migraine onset, thereby improving our understanding of the respective diseases' interactions.
methodsA systematic search of PubMed and EMBASE identified studies on pre-existing comorbidities as risk factors for new migraine onset. We performed three-level meta-analyses employing restricted maximum likelihood estimation to calculate pooled risk ratios (pRR). Subgroup and sensitivity analyses were conducted to assess the robustness of the data. Risk of bias (RoB) was assessed with the Quality in Prognostic Studies Tool. This review was pre-registered on Prospero (CRD42024501140).
resultsFrom a total of 17,330 records, we identified 38 studies, encompassing 124 effect sizes from 58 exposures. Most studies (n = 28, 74%) had a low RoB. Heterogeneity was high (>90%), primarily due to within-study differences (>50%), and was not significantly impacted by moderator tests or the exclusion of outliers. We found significantly increased risks for migraine onset associated with prior atopic conditions [pRR = 1.53 (1.15, 2.03)], psychiatric or psychological disorders [pRR = 2.63 (1.79, 3.85)], sleep disorders [pRR = 1.89 (1.26, 2.85)], and cardiovascular conditions [pRR = 1.72 (1.07, 2.76)].
conclusionsPre-existing atopic, psychiatric, sleep, and cardiovascular conditions are significantly associated with new migraine onset, likely due to shared genetic predisposition and mediating factors like stress and inflammation. Future research should focus on these associations to advance targeted prevention and treatment strategies.
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