Evidence map›Paper›PMID 40040236›Full record

ArticleJournal of natural products2025

Additional Bioactive Silvestrol Analogs from the Roots of

Ermias Mekuria Addo, Daniel Adu-Ampratwum, Elizabeth N Kaweesa, Garima Agarwal, Dmitriy Uchenik, Tran N Ninh, Djaja D Soejarto, Joanna E Burdette, James R Fuchs, A Douglas Kinghorn and 1 more

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ermias Mekuria AddoDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Daniel Adu-AmpratwumDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0001-9392-2431
Elizabeth N KaweesaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-9799-646X
Garima AgarwalDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Dmitriy UchenikCollege of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0009-0005-7929-4658
Tran N NinhVietnam Academy of Science and Technology, Hanoi, Vietnam.
Djaja D SoejartoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-7271-6847
James R FuchsDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-8743-6389
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-6647-8707
Harinantenaina L RakotondraibeDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-2166-4992

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
IRACDA at University of Illinois at ChicagoK12GM139186 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURDETTE, JOANNA E, NONN, LARISA · 2020 to 2024
$3.6M
Pharmacological Potential of Combined Translation and Autophagy Inhibition in High Grade Serous Ovarian CancerK99GM155616 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KAWEESA, ELIZABETH · 2024 to 2025
$242k
NCI NIH HHS P01 CA125066NCI NIH HHS P30 CA016058NIEHS NIH HHS P30 ES027792NIGMS NIH HHS K12 GM139186NIGMS NIH HHS K99 GM155616
6 · The paper itself

Abstract

The tropical plant

Indexed as

AglaiaPlant RootsTriterpenesAntineoplastic Agents, PhytogenicBenzofuransCell Line, TumorDrug Screening Assays, AntitumorHumansMolecular StructureVietnamAntineoplastic Agents, PhytogenicBenzofuranssilvestrolTriterpenes

Identifiers

PMID40040236
PMCPMC11960728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.