ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2024
Modulation of Cerebellar Nuclear Activity by Transcranial AC Stimulation in Awake Rats.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Transcranial alternating current stimulation of the cerebellum (ctACS) is an emerging neuromodulation technique that can potentially be leveraged to treat neurological disorders and improve learning in healthy individuals. Yet, the effects of ctACS on the neuronal circuits of the cerebellum is elusive. We implanted carbon fiber bundle electrodes in the interpositus nucleus of the cerebellum and an array electrode on the posterior surface of the skull for stimulation in chronic rats. Multi-unit activities (MUA) were recorded from three unanesthetized and quietly resting animals during transcranial application of the current stimuli at various frequencies (10 Hz-300 Hz) and amplitudes as well as after harmaline induced tremors. A frequency-spectrum based method for assessing the modulation strength from the MUA was developed. The results show that the interpositus MUA can be modulated transcranially in a range of frequencies with a peak modulation around 50 Hz. This agrees with an earlier report in general [1] although the peak frequency is lower. This study demonstrates the feasibility of entraining the activity of the cerebellar nuclear cells in awake animals by transcranial application of AC stimulation, as well as the detection of harmaline induced tremor from the MUAs. Future research will be directed towards testing the ctACS effects on this animal model of essential tremor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.