Evidence map›Paper›PMID 40039166›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2024

Perturbation-induced electromyographic activity is predictive of flexion synergy expression and a sensitive measure of post-stroke motor impairment.

Nirvik Sinha, Julius P A Dewald, Yuan Yang

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Beta-Band Cortico-Muscular Phase Coherence in Hemiparetic Stroke.Biomedical signal processing and control · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nirvik Sinha
Julius P A Dewald
Yuan Yang

Funding

EFFECT OF NEURAL CONSTRAINTS ON MOVEMENT IN STROKER01HD039343 · NICHD · REHABILITATION INSTITUTE OF CHICAGO · PI JULIUS P DEWALD, JUN YAO · 2000 to 2026
$6.0M
Contralesional Corticobulbospinal Structural and Functional Changes Post Stroke: Biomarkers for the upper limb flexion synergyR01NS105759 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P · 2019 to 2023
$2.7M
Shift from Unilateral to Bilateral Sensory-Motor Connectivity in Chronic Hemiparetic StrokeR01HD109157 · NICHD · UNIVERSITY OF OKLAHOMA · PI Yuan Yang · 2022 to 2026
$1.7M
Determination of the Recruitment of Indirect Motor Pathways in Chronic Hemiparetic StrokeR21HD099710 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, YANG, YUAN · 2019 to 2020
$416k
NICHD NIH HHS R01 HD039343NICHD NIH HHS R01 HD109157NICHD NIH HHS R21 HD099710NINDS NIH HHS R01 NS105759
6 · The paper itself

Abstract

The goal of this study was to explore whether the stretch reflex-induced muscle activity is correlated with the expression of the flexion synergy and, therefore, can serve as a quantitative indicator of post-stroke motor impairment. Eleven stroke participants stroke were recruited for this study. Their forearm was connected to a robotic device that applied continuous position perturbations to the paretic elbow joint. The magnitude of EMG activity of the spastic biceps brachii was measured. The expression of the flexion synergy was determined using the increase of synergistic elbow flexion torque when subjects were gradually lifting their paretic arm with two derived measures: normalized flexion synergy area (NFSA) and the mean slope of the expression of flexion synergy (ΔFS). Significant positive correlations were found between spastic biceps EMG (predictor variable) and the flexion synergy expression (response variables), i.e., NFSA (ρ = 0.89, p < 0.001) and ΔFS (ρ = 0.73, p = 0.01). This result indicates that the perturbation-induced EMG activity can serve as a sensitive indicator of post-stroke motor impairments related to the expression of spasticity and flexion synergy and demonstrates that these motor impairments may be mechanistically linked.

Indexed as

ElectromyographyStrokeAdultAgedFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscle Spasticity

Identifiers

PMID40039166
PMCPMC11883170

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.