ArticlePhotochemistry and photobiology
Feasibility of antimicrobial photodynamic therapy for treatment of breast abscesses: Retrospective Monte Carlo simulation study.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Laparoscopic Methylene Blue Photodynamic Therapy for Intraabdominal Infection: A Preclinical Feasibility Study in a Rabbit Model of Perforated Appendicitis.Lasers in surgery and medicine · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Breast abscesses are a common issue that affects both breastfeeding and nonpuerperal patients. Even with image-guided drainage and antibiotics, these recur frequently due to unresolved infection. One potential adjunct treatment is photodynamic therapy (PDT), which uses photosensitive compounds to generate cytotoxic reactive oxygen species. Here, we investigate the feasibility of using antimicrobial PDT to treat breast abscesses through a retrospective Monte Carlo simulation study. This study included adult subjects that had ultrasound-guided breast abscess aspiration over a five-year period at our institution (n = 119). Pre-procedure ultrasound images were segmented and used to produce either idealized ellipsoidal volumes or extrapolated segmented volumes for simulated PDT treatment planning. We investigated the effects of abscess wall optical properties and the presence of intra-cavity scattering on our ability to achieve target fluence rates of 4 or 20 mW/cm
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