ArticleThe Journal of clinical endocrinology and metabolism2025
Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case-Control Study in Sweden.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Eosinophilic Esophagitis and Autoimmune Thyroid Disease: A Population-Based Matched Cohort Study.United European gastroenterology journal · 2026Article
- Psychiatric morbidity following liothyronine exposure in autoimmune hypothyroidism: a Swedish nationwide cohort study.Journal of the Endocrine Society · 2026Article
- Microscopic colitis is associated with an increased risk of dementia in a Swedish population.Journal of internal medicine · 2026Article
- Increased risk of inflammatory bowel disease in ankylosing spondylitis compared to psoriasis.Frontiers in immunology · 2026Article
- Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case-Control Study in Sweden.The Journal of clinical endocrinology and metabolism · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
contextMicroscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is an inflammatory condition of the colon, characterized by watery diarrhea. Previous studies suggest an association between autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves disease) and MC; however, large-scale histology studies are lacking.
objectiveTo assess the association between AITDs and future onset of MC.
methodsWe conducted a nationwide, matched case-control study. Patients with biopsy-confirmed MC diagnosed between 2006 and 2017 were identified through the population-based histopathology cohort ESPRESSO. Data on AITDs and covariates were retrieved from Swedish national health care registers. Odds ratios (ORs) for MC associated with prior AITDs were estimated using conditional logistic regression. Sibling comparisons were performed to minimize shared genetic and environmental confounding.
resultsAmong 10 301 MC cases and 48 712 controls, AITDs were significantly more prevalent in MC patients (12.0%) than in controls (7.8%), yielding an adjusted OR of 1.65 (95% CI 1.54-1.77). This association was attenuated but remained significant in sibling analyses (OR 1.26; 95% CI 1.11-1.43) The association was stronger in patients diagnosed with MC before age 50 (OR 2.41; 95% CI 2.02-2.89). Subgroup analyses revealed no difference between CC and LC or between sexes.
conclusionIndividuals with AITDs are at an increased risk of developing MC. That this association was robust across various subgroups may be indicative of shared underlying mechanisms. Our findings highlight the importance of being vigilant of gastrointestinal symptoms in patients with AITDs and that patients with persistent symptoms despite achieving euthyroidism should be evaluated for MC.
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