Evidence map›Paper›PMID 40038808›Full record

ArticleStem cell research & therapy2025

Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX

Lei Wang, Ming Hao, Yongyue Xu, Zhaoyan Wang, Hanqi Xie, Bo Zhang, Xue Zhang, Jun Lin, Xiaodan Sun, Jianbin Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
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  7. Platelet-rich Plasma: ACurrent drug research reviews · 2026
    Review
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  9. Mitochondria transfer in tissue homeostasis and diseases.International journal of biological sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lei WangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Ming HaoSchool of Life Sciences, Tsinghua University, Beijing, 100084, China.
Yongyue XuMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Zhaoyan WangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Hanqi XieMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Bo ZhangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Xue ZhangMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Jun LinDepartment of Orthopaedics, Suzhou Dushu Lake Hospital, The Fourth Affiliated of Soochow University, Medical Center of Soochow University, Suzhou, 215001, Jiangsu, China.
Xiaodan SunSchool of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
Jianbin WangSchool of Life Sciences, Tsinghua University, Beijing, 100084, China.
Qiong WuMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China. wuqiong@tsinghua.edu.cn.

Funding

Horizon 2020 Framework Programme 870294Ministry of Science and Technology of the People's Republic of China 2018YFA0900100Ministry of Science and Technology of the People's Republic of China 2021YFC2101700National Natural Science Foundation of China 31961133017National Natural Science Foundation of China 31961133018National Natural Science Foundation of China 31961133019Vanke Special Fund for Public Health and Health Discipline Development of Tsinghua University 20221080049
6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic autoimmune disease and the integrity of CX

methodsTo explore the interaction between ADSCs and CX

resultsIntra-articular injection of ADSCs effectively attenuated the pathological progression of mice with serum transfer-induced arthritis. ADSCs gradually adhered to CX

conclusionsOur results suggest that ADSCs ameliorated the energy metabolism signature of CX

Indexed as

Adipose TissueArthritis, RheumatoidCX3C Chemokine Receptor 1MacrophagesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationSynovial MembraneAnimalsHumansMaleMiceMice, Inbred C57BLCX3C Chemokine Receptor 1Cx3cr1 protein, mouseMacrophageMesenchymal stem cellsMitochondriaRheumatoid arthritis

Identifiers

PMID40038808
PMCPMC11881422

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.