ArticleJournal of neuroinflammation2025
Extracellular mitochondria contribute to acute lung injury via disrupting macrophages after traumatic brain injury.
Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Circulating Extracellular Mitochondria Perpetuate Endothelial Damage via Cardiolipin-Mediated Mitophagic Overload.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Sympathetic Overactivation Drives Neurogenic Alveolar Epithelial Pyroptosis via the PIEZO2-ER Stress Pathway in Acute Lung Injury Following Intracerebral Hemorrhage.CNS neuroscience & therapeutics · 2026Article
- The brain-lung axis: Bridging neurological and respiratory disorders via neural-immune-microbial dialogue.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Review
- Pathological mechanisms and therapeutic potential of MSC-Exos in ischemic stroke management.Stem cell research & therapy · 2026Review
- African swine fever virus B66L drives extracellular mitochondrial release to promote systemic inflammation in mice.Nature communications · 2026Article
- Lung microbiota-derived deoxyinosine alleviates TBI-aggravated sepsis-induced lung injury via the S100A9/RAGE pathway.Journal of neuroinflammation · 2026Article
- Bone marrow-derived emergency monopoiesis drives brain-lung axis injury after traumatic brain injury via IL-1.Journal of neuroinflammation · 2025Article
- Lung protective ventilation alleviates intracerebral hemorrhage-induced secondary brain and lung injury in mice via the Nrf2/HO‑1 pathway.Journal of thoracic disease · 2025Article
- Bispecific self-assembled peptides as supra-growth factors for preventing endotheliopathy and improving survival of traumatic brain injury in mice.Journal of nanobiotechnology · 2025Article
- Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition.BMC chemistry · 2025Article
- Decoding mechanisms and protein markers in lung-brain axis.Respiratory research · 2025Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Acute lung injury (ALI) is the most frequently developed complication in patients with severe traumatic brain injury (TBI), but its underlying mechanism remains poorly understood. Here, we report results from a study designed to investigate the mechanistic link between TBI and ALI in mouse models, in vitro experiments, and a patient study, specifically focusing on the role of extracellular mitochondria (exMt). We detected high levels of exMt in the alveolar lavage fluid of patients with TBI. The bronchoalveolar lavage fluid (BALF) of mice subjected to controlled cerebral cortical impact contained 4.2 ± 1.4 × 10
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