Evidence map›Paper›PMID 40038665›Full record

SynthesisBMC medicine2025

Lifestyle behaviours do not moderate the association between childhood maltreatment and comorbid depression and cardiometabolic disease in older adults: a meta-analysis.

Olujolagbe Layinka, Camille Souama, Serena Defina, Vilte Baltramonaityte, Charlotte A M Cecil, Punit Shah, Yuri Milaneschi, Femke Lamers, Brenda W J H Penninx, Esther Walton

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olujolagbe LayinkaDepartment of Psychology, University of Bath, Building 10 West, Bath, BA2 7AY, UK.
Camille SouamaDepartment of Psychiatry, Amsterdam UMC Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Serena DefinaDepartment of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Vilte BaltramonaityteDepartment of Psychology, University of Bath, Building 10 West, Bath, BA2 7AY, UK.
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Punit ShahDepartment of Psychology, University of Bath, Building 10 West, Bath, BA2 7AY, UK.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam UMC Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Femke LamersDepartment of Psychiatry, Amsterdam UMC Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam UMC Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Esther WaltonDepartment of Psychology, University of Bath, Building 10 West, Bath, BA2 7AY, UK. E.Walton@bath.ac.uk.

Funding

European Research Council EP/Y015037/1Horizon 2020 Framework Programme 848158UK Research and Innovation EP/Y015037/1
6 · The paper itself

Abstract

backgroundComorbidity between depression and cardiometabolic diseases is an emerging health concern, with childhood maltreatment as a major risk factor. These conditions are also linked to unhealthy lifestyle behaviours such as physical inactivity, smoking, and alcohol intake. However, the precise degree to which lifestyle behaviours moderate the risk between childhood maltreatment and comorbid depression and cardiometabolic disease is entirely unknown.

methodsWe analysed clinical and self-reported data from four longitudinal studies (N

resultsNo meaningful moderation effects were detected for any of the lifestyle behaviours on the association between childhood maltreatment and each health outcome. Physical activity was linked to lower odds of depression (OR [95% CI] = 0.94 [0.92; 0.96]), while smoking was a risk factor for all three outcomes (OR [95% CI] = 1.16 [1.04; 1.31] or larger). Alcohol intake was associated with slightly lower odds of comorbidity (OR [95% CI] = 0.69 [0.66; 0.73]), although this association was not stable across all sensitivity analyses.

conclusionsLifestyle behaviours did not moderate the risk association between childhood maltreatment and depression, cardiometabolic disease, and their comorbidity in older adults. However, we confirmed that childhood maltreatment was associated with these conditions. Further research should address the limitations of this study to elucidate the most optimal targets for intervention.

Indexed as

Cardiovascular DiseasesChild AbuseDepressionLife StyleAgedAlcohol DrinkingChildComorbidityExerciseFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsSmokingAlcoholCardiometabolic diseaseChildhood maltreatmentComorbidityDepressionMeta-analysisPhysical activitySmoking

Identifiers

PMID40038665
PMCPMC11881505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.