ArticleBMC nephrology2025
Association between neutrophil percentage-to-albumin ratio and mortality in Hemodialysis patients: insights from a prospective cohort study.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Association of Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein-to-Albumin Ratio with Renal Anemia in Maintenance Hemodialysis Patients.Pakistan journal of medical sciences · 2026Article
- Threshold-dependent effect of the neutrophil-to-albumin ratio (NAR) in early pregnancy: a novel insight for preeclampsia risk prediction.American journal of translational research · 2026Article
- Neutrophil Percentage-to-Albumin Ratio as a Predictor of Urinary Tract Infection in Patients with Urinary Stone Disease: Development a Novel User-Friendly Tool.Journal of inflammation research · 2026Article
- Neutrophil Percentage-to-Albumin Ratio Predicts Contrast-Induced Acute Kidney Injury in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention.Journal of clinical medicine · 2025Article
- Sex-specific associations between Neutrophil-Percentage-to-Albumin Ratio(NPAR) and Neutrophil-to-Lymphocyte Ratio (NLR) with positive and negative symptoms in schizophrenia.BMC psychiatry · 2025Article
- Neutrophil percentage-to-albumin ratio as a predictor of In-hospital mortality in infective endocarditis.Biomarkers in medicine · 2025Article
- Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk.Cardiovascular diabetology · 2025Article
- Druggable Targets for Pelvic Inflammatory Disease: Mendelian Randomization and Experimental Validation.Journal of inflammation research · 2025Article
- Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors.Frontiers in aging neuroscience · 2025Article
- The Neutrophil Percentage-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Maintenance Hemodialysis Patients.International journal of general medicine · 2025Article
- Association of Neutrophil Percentage-to-Albumin Ratio with All-Cause and Cardiovascular Mortality in Maintenance Hemodialysis Patients: A Retrospective Study.Journal of inflammation research · 2025Article
- Association of the Neutrophil Percentage-to-Albumin Ratio with All-Cause Mortality in Patients with Hypercapnic Respiratory Failure: A Prospective Cohort Study.International journal of general medicine · 2025Article
- Association of Neutrophil Percentage-To-Albumin Ratio With All-Cause and Cardiovascular Mortality in Chronic Kidney Disease.Inquiry : a journal of medical care organization, provision and financingArticle
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22 authors.
Funding
Abstract
backgroundThe neutrophil percentage-to-albumin ratio (NPAR) emerges as a novel inflammation marker, demonstrating prognostic ability in a variety of cardiovascular diseases. However, its impact on mortality among patients undergoing maintenance hemodialysis (MHD) remains uncertain. Our research aims to determine whether NPAR is a reliable predictor of mortality in MHD patients.
methodsA total of 1803 MHD patients were recruited in this prospective cohort. Patients were stratified into three groups based on baseline NPAR levels. The association between NPAR and all-cause and cardiovascular mortality was evaluated using multivariate Cox proportional risk model and sensitivity analysis. NPAR's predictive performance was assessed using the receiver operating characteristic (ROC) curve, compared to several conventional biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil count, and serum albumin. The area under the curve (AUC) values of NPAR and these biomarkers were compared using the DeLong's test.
resultsThroughout a median follow-up period of 28 months, 239 (13.3%) patients died, with 91 (5.0%) dying of cardiovascular disease. Both all-cause mortality and cardiovascular mortality exhibited remarkably higher within the high NPAR group compared to the middle and low NPAR groups in the multivariate Cox regression analysis. The adjusted hazard ratio was 1.550 (95% CI: 1.110-2.166, P = 0.010) for all-cause mortality and 1.844 (95% CI: 1.058-3.212, P = 0.031) for cardiovascular mortality. This association was further corroborated by sensitivity analyses. The AUC values of NPAR for all-cause mortality and cardiovascular mortality were 0.612 (95% CI: 0.572-0.652, P < 0.001) and 0.618 (95% CI: 0.557-0.678, P < 0.001), separately. The p-values for comparing NPAR's AUC with those of NLR, PLR, neutrophils, and albumin were 0.307, 0.094, 0.014, and 0.154 for all-cause mortality, and 0.879, 0.126, 0.119, and 0.596 for cardiovascular mortality.
conclusionHigh NPAR level was independently associated with a higher increased risk of death in MHD patients.
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