Evidence map›Paper›PMID 40038584›Full record

ArticleBMC microbiology2025

Biocompatibility and photoinactivation evaluation of zinc hydroxide chloride nanosheets against Streptococcus mutans.

Shima Afrasiabi, Fatemeh Saghatchi, Ahmad Reza Dehpour, Ramin Goudarzi, Mohammad Reza Karimi, Alireza Partoazar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shima AfrasiabiLaser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh SaghatchiKnowledge-Based ImenNanoFam Company, Sciences and Technology Park of Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran.
Ahmad Reza DehpourDepartment of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ramin GoudarziDivision of Research and Development, Pharmin USA, LLC, San Jose, CA, USA.
Mohammad Reza KarimiPolymer Laboratory, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Alireza PartoazarExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. partoazar@tums.ac.ir.

Funding

Tehran University of Medical Sciences and Health Services 1402-4-158-67519
6 · The paper itself

Abstract

backgroundConsidering the efficacy of antimicrobial photodynamic therapy (PDT) in inactivating bacteria, this study reports that zinc hydroxide chloride nanosheets (ZHC-NSs) are useful for this purpose. MATERIALS &

methodsThe characterization of ZHC-NSs was performed using microscopic and spectroscopic techniques. The irritation test, acute toxicity test, and genotoxicity test of ZHC-NSs were evaluated and their effects on human pulp fibroblast cells (HPFC) viability, intracellular reactive oxygen species (ROS) levels, and antibacterial activity of ZHC-NSs (1-8 mg ml

resultsThe ZHC-NSs structure showed a crystalline form and their sheets' thickness had an average size of 129.6 ± 19.50 nm. ZHC-NSs did not severely damage internal organs and were not genotoxic. The cytotoxic effect of ZHC-NSs on HPFC was concentration-dependent so that ZHC-NSs at higher concentrations (4 and 8 mg ml

conclusionZHC-NSs

Indexed as

Anti-Bacterial AgentsBiocompatible MaterialsChloridesNanostructuresStreptococcus mutansZinc CompoundsBiofilmsCell SurvivalFibroblastsHumansPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesAnti-Bacterial AgentsBiocompatible MaterialsChloridesPhotosensitizing AgentsReactive Oxygen SpeciesZinc CompoundsCytotoxicityDental cariesNanomaterialsOxidative stressPhotochemotherapyStreptococcus mutansZinc hydroxide chloride

Identifiers

PMID40038584
PMCPMC11877797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.