Evidence map›Paper›PMID 40038522›Full record

ArticleThe Journal of antibiotics2025

The thiodiketopiperazine derivatives shovelmycin A-B and ansamycin derivative divergolide X from the cold-seep-derived Streptomyces olivaceus HDN22-001.

Chen Li, Jiangli Cheng, Ruojin Liu, Xiaofei Huang, Luning Zhou, Guojian Zhang, Tianjiao Zhu, Dehai Li, Qian Che

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen LiSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Jiangli ChengSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Ruojin LiuSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Xiaofei HuangSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Luning ZhouSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Guojian ZhangSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Tianjiao ZhuSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.
Dehai LiSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China.ORCID 0000-0002-7191-2002
Qian CheSchool of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, People's Republic of China. cheqian064@ouc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three new compounds including two thiodiketopiperazine derivatives shovelmycins A-B (1-2), and one ansamycin derivative divergolide X (3) were isolated and identified from the culture extract of Streptomyces olivaceus HDN22-001, a marine actinomycete obtained from the deep-sea cold seep sediment sample collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses and ECD calculations. Compound 1 exhibited the strongest DPPH radical scavenging activity with an IC

Indexed as

Antineoplastic AgentsDiketopiperazinesStreptomycesCell Line, TumorChinaFree Radical ScavengersHumansMolecular StructureAntineoplastic AgentsDiketopiperazinesFree Radical Scavengers

Identifiers

PMID40038522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.