ArticleScientific reports2025
The prevalence of hearing impairment in infants and children with down syndrome a cross sectional study in a Tertiary Care Center.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Beyond the nose: hearing status in 70 patients with congenital choanal atresia.European journal of pediatrics · 2026Article
- Review of early development in children with Down syndrome: family and clinician partnership.BMJ paediatrics open · 2026Review
- Rethinking Otorhinolaryngologic Care Pathways in Children with Down Syndrome: A Multidisciplinary Framework for Early Diagnosis and Management.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down syndrome is the most common chromosomal disorder in humans. Hearing impairment is a common feature of Down syndrome. To assess the prevalence of hearing impairment in children with DS attending the Mansoura University Children's Hospital. The study is a descriptive cross-sectional study on 170 pediatric patients with genetically confirmed DS. Patients were recruited from the genetic outpatient clinic of the Mansoura University Children's Hospital from October 2021 to October 2022. All infants and children were subjected to full history taking, and a lateral X-ray on the nasopharynx with open mouth and extended neck. The ears were examined and cleared from accumulated cerumen if present. The presence of middle ear pathology was assessed through an otoscopic examination of the tympanic membrane. Eustachian tube dysfunction and otitis media with effusion (OME) were assessed using tympanometry. Appropriate hearing tests including pure tone audiometry (PTA) and auditory brain stem response (ABR) were used. Conductive hearing loss (CHL) was observed in 48.8% of studied children with DS and 4.1% had sensorineural hearing loss (SNHL). Among patients with hearing impairment, 86.5% had bilateral affection. The severity of hearing loss was mild in 59.1% of patients with CHL and 71.4% with SNHL. Of the patients with CHL, HL remained stationary in 45.8%, regressed from moderate to mild HL in 15.7%, and normalized in 38.6%. SNHL was permanent in all 7 affected patients with a stationary course in 4 and a progressive nature in 3. OME, upper respiratory tract infections (URTI), and adenoid enlargement were commonly associated with CHL in infants and children with DS. Most children with DS have bilateral and mild hearing loss. HL is mostly conductive. Otitis media with effusion, adenoid enlargement, and recurrent upper RTI are common in patients with conductive hearing loss. Hearing assessment should be considered in all infants and children with Down syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.