Evidence map›Paper›PMID 40038285›Full record

ArticleNature communications2025

Crucial roles of Grr1 in splicing and translation of HAC1 mRNA upon unfolded stress response.

Nichika Sato, Yu Nakano, Yasuko Matsuki, Shota Tomomatsu, Sihan Li, Yoshitaka Matsuo, Toshifumi Inada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nichika SatoDivision of RNA and gene regulation, Institute of Medical Science, The University of Tokyo, Minato-Ku, Tokyo, 108-8639, Japan.
Yu NakanoGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Yasuko MatsukiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Shota TomomatsuDivision of RNA and gene regulation, Institute of Medical Science, The University of Tokyo, Minato-Ku, Tokyo, 108-8639, Japan.
Sihan LiDivision of RNA and gene regulation, Institute of Medical Science, The University of Tokyo, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-0224-5795
Yoshitaka MatsuoDivision of RNA and gene regulation, Institute of Medical Science, The University of Tokyo, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0001-9895-0028
Toshifumi InadaDivision of RNA and gene regulation, Institute of Medical Science, The University of Tokyo, Minato-Ku, Tokyo, 108-8639, Japan. toshiinada@ims.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-2695-588X

Funding

Japan Agency for Medical Research and Development (AMED) JP23gm1110010, JP223fa627001Japan Society for the Promotion of Science London (JSPS London) 21H00267, 23H04249, 23K23869,18H05498Japan Society for the Promotion of Science London (JSPS London) JP19H05281,21H05277, 22H00401MEXT | JST | Precursory Research for Embryonic Science and Technology (PRESTO) JPMJPR21EE
6 · The paper itself

Abstract

In the process of the unfolded protein response (UPR), the Hac1p protein is induced through a complex regulation of the HAC1 mRNA. This includes the mRNA localization on the endoplasmic reticulum (ER) membrane and stress-triggered splicing. In yeast, a specific ribosome ubiquitination process, the monoubiquitination of eS7A by the E3 ligase Not4, facilitates the translation of HAC1

Indexed as

Basic-Leucine Zipper Transcription FactorsF-Box ProteinsMinor Histocompatibility AntigensRepressor ProteinsRNA SplicingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitin-Protein LigasesUnfolded Protein ResponseEndoplasmic ReticulumGene Expression Regulation, FungalProtein BiosynthesisRNA, MessengerUbiquitinationBasic-Leucine Zipper Transcription FactorsF-Box ProteinsHAC1 protein, S cerevisiaeMinor Histocompatibility AntigensRepressor ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsUbiquitin-Protein Ligases

Identifiers

PMID40038285
PMCPMC11880305

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.