ArticleNature communications2025
Mechanistic insights into nonlinear effects in copper-catalyzed asymmetric esterification.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cu-Catalyzed Asymmetric Carbene Insertion into N-H, O-H, and S-H Bonds: Challenging the Existing Mechanistic Dogma.JACS Au · 2025Article
- Synthesis of chiral germanium center enabled by poly-deborylative alkylation and desymmetrization.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonlinear effects (NLEs) serve as a widespread tool in the study of asymmetric catalytic reactions. However, due to the diversity in ligand-metal coordination modes, the information obtained solely from the linear relationship between the ee values of ligands and products in complex systems is often indirect. Here, we report a precise method that directly connects the relationship between the ee values of metal complexes and products, with the purpose of determining the active species that occur in complex systems. Through an in-depth analysis of the mechanism of our previous copper-catalyzed asymmetric esterification reactions, we find an intrinsic linear relationship between the ee values of the key active metal complex (LLCu
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.