Evidence map›Paper›PMID 40038197›Full record

ArticleMolecular neurobiology2025

From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role Uncovered.

Ran Gao, Yaqi Xu, Min Zhang, Qi Zeng, Gaizhi Zhu, Wenting Su, Renxi Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Microglial Feimin Alleviates Cognitive Impairment in High-Fat Diet-Fed Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ran GaoBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.
Yaqi XuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.
Min ZhangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.
Qi ZengBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.
Gaizhi ZhuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.
Wenting SuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China. wtsu@ccmu.edu.cn.
Renxi WangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China. renxi_wang@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is a leading cause of death and disability worldwide. It is crucial to understand the influencing factors and potential mechanisms of stroke, as well as reducing its risk. This study identified the expression of the B230219D22Rik gene in mouse microglial cells, corresponding to the human gene C5orf24, using the NCBI database. We then validated the role of C5orf24 in stroke using quantitative real-time PCR, enzyme-linked immunosorbent assay, western blot and Mendelian randomization (MR) analysis. Additionally, we evaluated the causal association of C5orf24 with three other vascular diseases: coronary heart disease, myocardial infarction, and embolism. The gene B230219D22Rik and C5orf24 expressed in microglia was observed to have reduced expression in mouse and human cell stroke models, respectively. In MR analysis, we found a significant causal relationship between increased C5orf24 levels and reduced stroke risk (OR = 0.68, 95% CI 0.48-0.98, P = 4.07 × 10

Indexed as

Genetic Predisposition to DiseaseMitochondrial ProteinsStrokeAnimalsCell LineHumansMendelian Randomization AnalysisMiceMicrogliaRisk FactorsMitochondrial ProteinsB230219D22RikC5orf24IL-1βIL-6Inflammatory factorsMendelian randomizationStrokeVascular diseases

Identifiers

PMID40038197

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.