ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2025
The landscape of decidual immune cells at the maternal-fetal interface in parturition and preterm birth.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Narrative Review on Therapies That Influence Inflammatory Responses During Extremely Premature Perinatal Respiratory Transition.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Targeting NF-κB Signaling in Preterm Labor: Molecular Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Toxoplasma gondii infection reduces CD59 expression through downregulation of JAK2/STAT3 signaling axis to enhance decidual NK cell cytotoxicity via the RAS/MAPK pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Review
- Mincle Receptor Deficiency Protects Against LPS-induced Preterm Birth and Fetal Inflammatory Response Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Histopathological placental inflammation and umbilical cord blood inflammatory biomarkers in preterm infants: a prospective cohort study.BMC pregnancy and childbirth · 2026Article
- IGFBP3 repression driven by inflammation links air pollution to placental and developmental defects.EMBO molecular medicine · 2026Article
- Regulatory T cells in pregnancy disorders: a multi-dimensional framework for biomarkers and therapeutic strategies.Frontiers in immunology · 2026Review
- Cytokine profiling of maternal peripheral and umbilical cord blood in term and preterm labor.Frontiers in immunology · 2026Article
- Identification of cell senescence-related genes in spontaneous preterm birth based on bioinformatics analysis and machine learning.PloS one · 2026Article
- Regulatory T cells in human pregnancy: mechanisms, dysregulation, and therapeutic perspectives.Frontiers in immunology · 2026Review
- M2 macrophages undergoing ferroptosis regulate uterine smooth muscle contraction to facilitate labor onset.Scientific reports · 2025Article
- The placenta as a window into neonatal brain injury.Seminars in perinatology · 2025Review
- Fetal response to maternal exposures of environmental chemicals: Utility of a four-cell human feto-maternal interface organ-on-chip.Chemico-biological interactions · 2025Article
- Trem2-MICAL1-P-ERK Axis in Macrophages Confers Protection AgainstPathogens (Basel, Switzerland) · 2025Article
- Dynamics of Macrophage Polarization Reveal Unique Phenotypes During Mouse Postpartum Uterine Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Article
- Capillary leak syndrome following cesarean section in a patient with severe preeclampsia: a case report.Frontiers in medicine · 2025Article
- Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundParturition is similar to an inflammatory response in which resident and infiltrating immune cells release cytokines and chemokines into the maternal-fetal interface, promoting expulsion of the fetus from the mother. The untimely activation of these inflammatory pathways can result in preterm labor. The maternal-fetal interface is composed mainly of decidual tissue and placental villous space.
objectiveThe objective of this review is to examine the role and mechanisms of decidual immune cells during parturition and preterm birth. A deeper understanding of decidual immune cells at the maternal-fetal interface could provide significant insight into parturition and preterm birth pathogenesis.
methodsWe searched major databases (including PubMed, Web of Science, and Google Scholar etc.) for literature encompassing decidual immune cells, parturition and preterm birth up to July 2024 and combined with studies found in the reference lists of the included studies.
resultsDecidual neutrophils release inflammatory mediators that facilitate parturition. The M1/M2 ratio of decidual macrophages increases among preterm birth population. Mast cells may cause uterine contractions. In parturition and preterm birth, there is an increase in CD56
conclusionThe dynamic balance of the maternal-fetal immune microenvironment plays a crucial role in maintaining human pregnancy and in the initiation of delivery. A deep understanding of the mechanism of decidual immune dysfunction is crucial for understanding the pathogenesis of preterm birth.
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Registered trials
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