ArticleSchizophrenia bulletin2025
Amygdala Function, Blood Flow, and Functional Connectivity in Nonclinical Schizotypy.
Article in Schizophrenia bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Acute susceptibility changes of deep gray matter nuclei to gadobutrol: a prospective longitudinal study using quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2026Article
- I fear you're getting too close: neural correlates of personal space violation in paranoia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Neuroscience of Schizotypy: A Translational Perspective From Phenotype to Genetics and Brain Networks.Schizophrenia bulletin · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
background and hypothesisSchizotypy can be utilized as a phenotypic risk marker for schizophrenia and its spectrum and might relate to putative dimensional biological markers of the psychosis spectrum. Among these are amygdala function and structure, which are impaired in schizophrenia, but possibly also correlated with subclinical expression of schizotypy in nonclinical samples. We tested whether different parameters relating to amygdala function would be different in healthy subjects with relatively higher vs lower schizotypy traits. STUDY
designSixty-three psychiatrically healthy subjects (42 with higher vs 21 with lower schizotypy scores, selected on the basis of the Oxford-Liverpool Inventory of Feelings and Experiences positive schizotypy subscale) underwent a multimodal imaging protocol, including functional magnetic resonance imaging (fMRI) during a task-based emotional (fearful) face recognition paradigm, arterial spin labeling for measurement of regional cerebral blood flow (rCBF) at rest, and resting-state fMRI for functional connectivity (FC) analyses, as well as a T1-weighted structural MRI scan. STUDY
resultsThe high schizotypy group showed significantly higher right amygdala activation during viewing of fearful emotional images and lower resting-state FC of the left amygdala with a cerebellum cluster, but no differences in resting-state amygdala rCBF or volume.
conclusionsOur findings demonstrate a functionally relevant effect of schizotypy on amygdala activation in the absence of baseline rCBF or macroscopic structure. This suggests that while schizotypy might affect some functional or structural parameters in the brain, certain functionally relevant effects only emerge during cognitive or emotional triggers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.