Evidence map›Paper›PMID 40037698›Full record

ArticleAJNR. American journal of neuroradiology2025

Diffusion- and Tractography-Based Characterization of Tissue Damage Within and Surrounding Paramagnetic Rim Lesions in Multiple Sclerosis.

Maryam Mohebbi, Jack A Reeves, Dejan Jakimovski, Alexander Bartnik, Niels Bergsland, Fahad Salman, Ferdinand Schweser, Bianca Weinstock-Guttman, Robert Zivadinov, Michael G Dwyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maryam MohebbiFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.
Jack A ReevesFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.
Dejan JakimovskiFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.ORCID 0000-0001-7114-4958
Alexander BartnikFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.
Niels BergslandFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.ORCID 0000-0002-7792-0433
Fahad SalmanFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.
Ferdinand SchweserFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.ORCID 0000-0003-0399-9211
Bianca Weinstock-GuttmanJacobs Neurological Institute (B.W.-G.), Buffalo, New York.ORCID 0000-0001-6732-151X
Robert ZivadinovFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.ORCID 0000-0002-7799-1485
Michael G DwyerFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York mgdwyer@buffalo.edu.ORCID 0000-0003-4684-4658

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeParamagnetic rim lesions (PRLs) are an imaging biomarker of chronic inflammation in MS that are associated with more aggressive disease. However, the precise tissue characteristics and extent of their damage, particularly with regard to connected axonal tracts, are incompletely understood. Quantitative diffusion tissue measurements and fiber tractography can provide a more complete picture of these phenomena. MATERIALS AND

methodsOne hundred fifteen people with MS were enrolled in this study. Quantitative susceptibility mapping and DWI were acquired on a 3T MRI scanner. PRLs were identified in 49 (43%) subjects. Diffusion tractography was then used to identify nearby PRL-connected versus non-PRL connected tracts and PRL-connected versus nonconnected surrounding tracts. DWI metrics, including fractional anisotropy (FA), quantitative anisotropy (QA), mean diffusivity, axial diffusivity, radial diffusivity, isotropy, and restricted diffusion imaging, were compared between these tracts and within PRLs and non-PRL lesions themselves.

resultsTissue within PRLs had significantly lower FA than tissue within non-PRL T2 lesions (

conclusionsPRLs are more destructive both within themselves and to surrounding tissue. This damage appears more spatially than axonally mediated.

Indexed as

BrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingMultiple SclerosisAdultFemaleHumansMaleMiddle AgedReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID40037698
PMCPMC11979825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.