Observational studyBMJ open2025
Patients' acceptability, adherence and satisfaction on the modified shorter all-oral multidrug-resistant tuberculosis regimen: a two-phase cross-sectional study in Tanzania.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness and Safety of Bedaquiline-Containing Modified Shorter Regimens for Multidrug- or Rifampicin-Resistant Tuberculosis: A Single-Arm Meta-Analysis.Pathogens (Basel, Switzerland) · 2026Pooled it
- Treatment Adherence With an Oral 9-Month Regimen for Rifampicin-Resistant Tuberculosis in South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- Effectiveness and safety of a shortened oral regimen for rifampicin- or multidrug-resistant TB.IJTLD open · 2026Article
- Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis.PLOS global public health · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine patients' acceptability, satisfaction and adherence to shorter all-oral multidrug-resistant tuberculosis (MDR-TB) regimen in Tanzania.
designA two-phase cross-sectional study with data collected within 6 months of Removed Injectable modified Short-course regimens for EXpert MDR-TB (RISE) study implementation and the second phase within 15 months of implementation using the same reference populations. SETTINGS: 18 health facilities across eight regions of Tanzania.
participantsRifampicin-resistant TB/MDR-TB patients enrolled in the RISE study. OUTCOME MEASURES: We assessed patients' acceptability, adherence and satisfaction with the regimen using an interval scale structured questionnaire.
resultsThe majority of the patients found the shorter oral MDR-TB treatment acceptable, adhered to it well and were generally satisfied. The median score (IQR) for acceptability was 1.7 (1.03-2.00) but it ranged between 1.3 (1.3-2) and 1.7 (1-1.79) for the first and second phases, respectively. Regarding adherence, the median score (IQR) stood at 4 (3.67-4.67) with scores significantly higher in the second phase at 4.33 (4.00-5.007) compared with the first at 4.67 (4.00-5.0), p value=0.01. The overall satisfaction was high at 1.5 (1.33-1.78) but it ranged between 1.22 (1.00-1.78) and 1.42 (1.11-1.78) for the first and second phases, respectively. Worrying about side effects was statistically associated with adherence (p value<0.05). No statistically significant associations were found for acceptability and satisfaction.
conclusionGenerally, the modified shorter oral MDR-TB regimen was accepted, and patients reported good adherence and were satisfied. More engagement with patients could provide more insights into factors that can maximise acceptability, adherence and satisfaction with the regimen.
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