Evidence map›Paper›PMID 40037609›Full record

ArticleMedical mycology2025

Comparison of broth microdilution and Etest® methods for susceptibility testing of amphotericin B in Candida auris.

Domenica G De Luca, Xiao Rui Li, David C Alexander, Tanis C Dingle, Philippe J Dufresne, Linda M Hoang, Julianne V Kus, Caroline Sheitoyan-Pesant, Amrita Bharat

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clinical and Microbiological Characteristics of EarlyAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Resistance gene mutations and phylogenetic relationships inFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Domenica G De LucaNational Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada.
Xiao Rui LiNational Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada.
David C AlexanderDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada.
Tanis C DingleAlberta Precision Laboratories - Public Health Laboratory, Calgary, AB, T2N 4W4, Canada.
Philippe J DufresneLaboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, QC, H9X 3R5, Canada.
Linda M HoangBC Centre for Diseases Control, Vancouver, BC, V5Z 4R4, Canada.
Julianne V KusPublic Health Ontario, Toronto, ON, M5G 1M1, Canada.
Caroline Sheitoyan-PesantCentre hospitalier universitaire Dr-Georges-L.-Dumont, Moncton, NB E1C 2Z3, Canada.
Amrita BharatNational Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada.ORCID 0000-0003-4171-9436

Funding

Genomics Research and Development Initiative
6 · The paper itself

Abstract

Amphotericin B remains an important treatment for multidrug-resistant Candida auris. Antifungal susceptibility testing of amphotericin B in C. auris can vary depending on the methodology used. Here, we compared the Etest method and the Clinical and Laboratory Standards Institute broth microdilution reference method for amphotericin B against 60 clinical C. auris isolates from the four major clades. The minimum inhibitory concentrations differed significantly by method (P-value, <.0001), and discrepancies were observed in the interpretation of resistance (categorical agreement, 88.3%; very major error, 33.3%). Broth microdilution may represent a more conservative approach for detecting amphotericin B resistance in C. auris.

Indexed as

Amphotericin BAntifungal AgentsCandidaCandida aurisCandidiasisDrug Resistance, FungalHumansMicrobial Sensitivity TestsAmphotericin BAntifungal Agentsamphotericin Bantifungal susceptibility testingbroth microdilutionCandida aurisEtest

Identifiers

PMID40037609
PMCPMC11899573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.