Evidence map›Paper›PMID 40037540›Full record

ReviewNeuro-oncology2025

Applications of artificial intelligence and advanced imaging in pediatric diffuse midline glioma.

Atlas Haddadi Avval, Suneel Banerjee, John Zielke, Benjamin H Kann, Sabine Mueller, Andreas M Rauschecker

Abstract readReview
In one paragraph

Review in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Atlas Haddadi AvvalCenter for Intelligent Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco (UCSF), San Francisco, California, USA.ORCID 0000-0002-3896-7810
Suneel BanerjeeMedical Scientist Training Program (MSTP), University of California San Diego (UCSD), San Diego, California, USA.ORCID 0000-0001-7695-8002
John ZielkeDepartment of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Benjamin H KannDepartment of Radiation Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.
Sabine MuellerDepartment of Neurology, Department of Neurosurgery and Department of Pediatrics, UCSF, San Francisco, California, USA.
Andreas M RauscheckerCenter for Intelligent Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco (UCSF), San Francisco, California, USA.ORCID 0000-0003-0633-9876

Funding

DMG Precision Medicine
6 · The paper itself

Abstract

Diffuse midline glioma (DMG) is a rare, aggressive, and fatal tumor that largely occurs in the pediatric population. To improve outcomes, it is important to characterize DMGs, which can be performed via magnetic resonance imaging (MRI) assessment. Recently, artificial intelligence (AI) and advanced imaging have demonstrated their potential to improve the evaluation of various brain tumors, gleaning more information from imaging data than is possible without these methods. This narrative review compiles the existing literature on the intersection of MRI-based AI use and DMG tumors. The applications of AI in DMG revolve around classification and diagnosis, segmentation, radiogenomics, and prognosis/survival prediction. Currently published articles have utilized a wide spectrum of AI algorithms, from traditional machine learning and radiomics to neural networks. Challenges include the lack of cohorts of DMG patients with publicly available, multi-institutional, multimodal imaging and genomics datasets as well as the overall rarity of the disease. As an adjunct to AI, advanced MRI techniques, including diffusion-weighted imaging, perfusion-weighted imaging, and Magnetic Resonance Spectroscopy (MRS), as well as positron emission tomography (PET), provide additional insights into DMGs. Establishing AI models in conjunction with advanced imaging modalities has the potential to push clinical practice toward precision medicine.

Indexed as

Artificial IntelligenceBrain NeoplasmsGliomaMagnetic Resonance ImagingNeuroimagingChildHumansPrognosisartificial intelligencedeep learningdiffuse intrinsic pontine gliomadiffuse midline gliomaradiomics

Identifiers

PMID40037540
PMCPMC12309720

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.