Evidence map›Paper›PMID 40037522›Full record

ArticleBioinformatics (Oxford, England)2025

GeneFEAST: the pivotal, gene-centric step in functional enrichment analysis interpretation.

Avigail Taylor, Valentine M Macaulay, Matthieu J Miossec, Anand K Maurya, Francesca M Buffa

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Pathway Analysis Interpretation in the Multi-Omic Era.Biotech (Basel (Switzerland)) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Avigail TaylorNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.ORCID 0000-0002-8199-1007
Valentine M MacaulayNuffield Department of Surgical Sciences, University of Oxford, ORCRB, Oxford OX3 7DQ, United Kingdom.
Matthieu J MiossecCentre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.
Anand K MauryaNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Francesca M BuffaComputational Biology & Integrative Genomics Lab, Department of Oncology, University of Oxford, ORCRB, Oxford OX3 7DQ, United Kingdom.ORCID 0000-0003-0409-406X

Funding

Cancer Research UK C476/A27060University of Oxford Returning Carer's FundWellcome 203141/Z/16/ZWellcome Trust
6 · The paper itself

Abstract

summaryGeneFEAST, implemented in Python, is a gene-centric functional enrichment analysis summarization and visualization tool that can be applied to large functional enrichment analysis (FEA) results arising from upstream FEA pipelines. It produces a systematic, navigable HTML report, making it easy to identify sets of genes putatively driving multiple enrichments and to explore gene-level quantitative data first used to identify input genes. Further, GeneFEAST can juxtapose FEA results from multiple studies, making it possible to highlight patterns of gene expression amongst genes that are differentially expressed in at least one of multiple conditions, and which give rise to shared enrichments under those conditions. Thus, GeneFEAST offers a novel, effective way to address the complexities of linking up many overlapping FEA results to their underlying genes and data, advancing gene-centric hypotheses, and providing pivotal information for downstream validation experiments. AVAILABILITY AND IMPLEMENTATION: GeneFEAST GitHub repository: https://github.com/avigailtaylor/GeneFEAST; Zenodo record: 10.5281/zenodo.14753734; Python Package Index: https://pypi.org/project/genefeast; Docker container: ghcr.io/avigailtaylor/genefeast.

Indexed as

Computational BiologySoftwareGene Expression Profiling

Identifiers

PMID40037522
PMCPMC11919446

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.