Evidence map›Paper›PMID 40037382›Full record

Trial reportEuropean heart journal2025

High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial.

Joyee Basu, Dimitra Nikoletou, Chris Miles, Hamish MacLachlan, Gemma Parry-Williams, Fred Tilby-Jones, Paulo Bulleros, Zephryn Fanton, Claire Baker, Shane Purcell and 17 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077005 (MavaEnEx-HOCM), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07077005 narecruitingnot on this map

MavaEnEx-HOCM: Mavacamten Enables Exercise Training in Patients With Hypertrophic Obstructive CardioMyopathy. A Pilot Study

TypeinterventionalSponsorTechnical University of MunichRan2025 to 2027Enrolled24ConditionsCardiomyopathy, HypertrophicArmsExercise training
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Physical activity in hypertrophic cardiomyopathy: from proscription to prescription.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  6. Article
  7. Review
  8. Review
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  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Joyee BasuCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.ORCID 0000-0003-1339-665X
Dimitra NikoletouCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Chris MilesCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.ORCID 0000-0002-8192-5739
Hamish MacLachlanCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Gemma Parry-WilliamsCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Fred Tilby-JonesCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Paulo BullerosCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Zephryn FantonCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Claire BakerCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Shane PurcellCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Carmen LechCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Tracy ChapmanCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Peter SageCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Shams WahidCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Nabeel SheikhGuy's and St Thomas' NHS Foundation Trust, London, UK.
Shruti JayakumarCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Aneil MalhotraCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Tracey Keteepe-ArachiCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Belinda GrayCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.ORCID 0000-0002-9966-0329
Gherardo FinocchiaroCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Gerald Carr-WhiteGuy's and St Thomas' NHS Foundation Trust, London, UK.
Elijah BehrCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.ORCID 0000-0002-8731-2853
Maite TomeCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Jamie O'DriscollCardiovascular Clinical Academic Group, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London SW17 0QT, UK.
Irina Chis SterCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.
Sanjay SharmaCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.ORCID 0000-0002-3630-6138
Michael PapadakisCardiovascular and Genomic Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK†.

Funding

Cardiac Risk in the Young 1050845
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe feasibility and impact of high intensity exercise programmes in patients with hypertrophic cardiomyopathy (HCM) are unknown. This study was conducted to determine the feasibility of a high intensity exercise programme and explore safety and efficacy outcomes in patients with HCM.

methodsParticipants were randomized to a 12-week supervised exercise programme (n = 40) in addition to usual care, or usual care alone (n = 40). All participants underwent assessment at baseline and 12 weeks. The exercise group was re-evaluated 6 months post-programme. Feasibility was assessed by (i) recruitment, adherence, and retention rates; (ii) staffing ratios; (iii) logistics; and (iv) acceptability of the intervention. The primary exploratory safety outcome was a composite of arrhythmia-related events. Exploratory secondary outcomes included changes in (i) cardiorespiratory fitness; (ii) cardiovascular risk factors; and (iii) quality of life, anxiety, and depression scores.

resultsOverall, 67 (84%) participants completed the study (n = 34 and n = 33 in the exercise and usual care groups, respectively). Reasons for non-adherence included travel, work, and family commitments. Resource provision complied with national cardiac rehabilitation standards. There was no difference between groups for the exploratory safety outcome (P = .99). At 12 weeks, the exercise group had a greater increase in peak oxygen consumption (VO2) [+4.1 mL/kg/min, 95% confidence interval (CI) 1.1, 7.1] and VO2 at anaerobic threshold (+2.3 mL/kg/min, 95% CI 0.4, 4.1), lower systolic blood pressure (-7.3 mmHg, 95% CI -11.7, -2.8) and body mass index (-0.8 kg/m2, 95% CI -1.1, -0.4), and greater improvement in hospital anxiety (-3, 95% CI -4.3, -1.7) and depression (-1.7, 95% CI -2.9, -0.5) scores, compared to the usual care group. Most exercise gains dissipated at 6 months.

conclusionsA high intensity exercise programme is feasible in patients with HCM, with apparent cardiovascular and psychological benefits, and no increase in arrhythmias. A large-scale study is required to substantiate findings and assess long-term safety of high intensity exercise in HCM.

Indexed as

Cardiomyopathy, HypertrophicExercise TherapyAdultAgedAnxietyCardiorespiratory FitnessFeasibility StudiesFemaleHumansMaleMiddle AgedPatient ComplianceQuality of LifeTreatment OutcomeCardiac rehabilitationHigh intensity exerciseHypertrophic cardiomyopathySports cardiology

Identifiers

PMID40037382
PMCPMC12075935

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.