Evidence map›Paper›PMID 40037349›Full record

ArticleCurrent biology : CB2025

Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states.

Kauê Machado Costa, Zhewei Zhang, Douglas Deutsch, Yizhou Zhuo, Guochuan Li, Yulong Li, Geoffrey Schoenbaum

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. A brief history of dopamine prediction errors.Frontiers in computational neuroscience · 2026
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kauê Machado CostaNational Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35223, USA. Electronic address: kaue.m.costa@gmail.com.
Zhewei ZhangNational Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: zhewei.zhang@nih.gov.
Douglas DeutschNational Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Yizhou ZhuoState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Guochuan LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Yulong LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Chinese Institute for Brain Research, Beijing 102206, China; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China; National Biomedical Imaging Center, Peking University, Beijing 100871, China.
Geoffrey SchoenbaumNational Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: geoffrey.schoenbaum@nih.gov.

Funding

Associative learning, decision-making, and addictionZIADA000587 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SCHOENBAUM, GEOFFREY · 2012 to 2025
$47.7M
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
Information encoding by spatiotemporal patterns of dopamine releaseR00DA055641 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kauê Machado Costa · 2024 to 2026
$747k
Intramural NIH HHS ZIA DA000587NIDA NIH HHS K99 DA055641NIDA NIH HHS R00 DA055641NINDS NIH HHS U01 NS120824
6 · The paper itself

Abstract

Dopamine release in the nucleus accumbens (NAcc) changes quickly in response to errors in predicting events like reward delivery

Indexed as

AcetylcholineBehavior, AnimalDopamineNucleus AccumbensAnimalsMaleRatsRewardAcetylcholineDopamineacetylcholineapproachdopaminefiber photometryinstrumentalmotivationrampsratreward prediction errorsalience

Identifiers

PMID40037349
PMCPMC11948157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.