Evidence map›Paper›PMID 40037273›Full record

ArticleInternational journal of surgery case reports2025

Acute abdominopelvic pain and distension in a 21-year-old woman revealing a mixed germ cell tumor: A case report.

Dhekra Toumi, Chayma Cheikh Mohamed, Imen Ghaddab, Amina Ben Salem, Ahlem Bellalah, Ahmed Hajji

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Article in International journal of surgery case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Dhekra ToumiFaculty of Medicine of Monastir, Department of Gynecology and Obstetrics, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Chayma Cheikh MohamedFaculty of Medicine of Monastir, Department of Gynecology and Obstetrics, Fattouma Bourguiba University Hospital, Monastir, Tunisia. Electronic address: chayma.cheikhmohamed@gmail.com.
Imen GhaddabFaculty of Medicine of Monastir, Department of Gynecology and Obstetrics, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Amina Ben SalemFaculty of Medicine of Monastir, Department of Radiology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Ahlem BellalahFaculty of Medicine of Monastir, Department of Anatomical Pathology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Ahmed HajjiFaculty of Medicine of Monastir, Department of Gynecology and Obstetrics, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and importancePrimary ovarian germ cell tumors (OGCTs) account for 5 % of malignant pelvic neoplasms, predominantly affecting young females and often presenting as medical emergencies. Among OGCTs, malignant mixed germ cell tumors constitute approximately 8 % of cases and are characterized by their aggressive nature. Early and appropriate management of these rare tumors is crucial for optimizing patient outcomes. CASE PRESENTATION: We present the case of a 21-year-old female who was admitted urgently due to a large abdominopelvic mass. Clinical evaluation and supplementary investigations confirmed the diagnosis of a mixed OGCT, featuring the most common combination of yolk sac tumor and dysgerminoma. A transvaginal surgical approach was employed to preserve the patient's hymenal integrity and facilitate oocyte preservation, in accordance with her cultural and personal beliefs. The treatment consisted of unilateral adnexectomy followed by platinum-based chemotherapy. CLINICAL DISCUSSION: Mixed OGCTs are rare but highly aggressive tumors that primarily affect young women. Despite their aggressive nature, these tumors often have a favorable prognosis when promptly diagnosed and treated. This case highlights the importance of individualized, fertility-preserving approaches in young patients. The combination of yolk sac tumor and dysgerminoma necessitated a multimodal treatment strategy to achieve optimal outcomes while respecting the patient's reproductive aspirations.

conclusionMixed OGCTs are uncommon neoplasms that require early diagnosis and tailored management. This case is noteworthy due to the rare presentation of a mixed germ cell tumor in a young woman and the multidisciplinary approach undertaken to balance oncological management with fertility preservation, utilizing a transvaginal surgical technique to respect the patient's cultural and personal beliefs.

Indexed as

Chemotherapy sensitivityCryo preservationPrimary ovarian germ cell tumorsUnilateral adnexectomyYoung woman

Identifiers

PMID40037273
PMCPMC11923803

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