Evidence map›Paper›PMID 40037117›Full record

ArticleClinical biomechanics (Bristol, Avon)2025

Altered cumulative joint moments and increased joint moment symmetry during sit-to-stand transitions for transfemoral bone-anchored limb users: A case series.

Peter B Thomsen-Freitas, Jason W Stoneback, James B Tracy, Mohamed E Awad, Danielle H Melton, Brecca M M Gaffney, Cory L Christiansen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter B Thomsen-FreitasDepartment of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: peter.thomsen-freitas@cuanschutz.edu.
Jason W StonebackDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
James B TracyDepartment of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Mohamed E AwadDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Danielle H MeltonDepartment of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brecca M M GaffneyVA Eastern Colorado Healthcare System, Aurora, CO, USA; Department of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cory L ChristiansenDepartment of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA; University of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
Interdisciplinary Training in Musculoskeletal ResearchT32AR080630 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Karin A Payne, MICHAEL J ZUSCIK · 2022 to 2026
$1.7M
Effect of Osseointegrated Prostheses on the Pathogenesis of Hip Osteoarthritis in Patients with Lower Limb LossK01AR080776 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Brecca Gaffney · 2023 to 2026
$522k
Dynamic Bone-Implant Loading in Osseointegrated ProsthesesR03HD111012 · NICHD · UNIVERSITY OF COLORADO DENVER · PI GAFFNEY, BRECCA · 2023 to 2024
$289k
NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NIAMS NIH HHS K01 AR080776NIAMS NIH HHS T32 AR080630NICHD NIH HHS R03 HD111012
6 · The paper itself

Abstract

backgroundSit-to-stand transitions are demanding activities for people with unilateral transfemoral amputation. Movement asymmetries during sit-to-stand place greater stresses on the intact limb joints compared to the amputated limb joints, potentially contributing to musculoskeletal overuse injury and pain. Bone-anchored limbs address socket-related prosthesis issues, but their impact on cumulative joint moments during sit-to-stand is yet to be fully understood. The purpose of this study was to investigate changes in cumulative joint moments and moment symmetry during sit-to-stand transitions among transfemoral bone-anchored limb users.

methodsA case-series of eight participants who underwent secondary bone-anchored limb implantation surgery were included. Ten consecutive days of physical activity monitoring (daily sit-to-stand) and motion capture during a 5-times sit-to-stand task were collected preoperatively (using socket prosthesis) and 12-months postoperatively. Cumulative low back, hip, and knee joint moments ([absolute joint moment impulse] x [average daily sit-to-stand]) were calculated. Between-limb symmetry was assessed using the Normalized Symmetry Index. Longitudinal changes in cumulative joint moments and moment symmetry were estimated with Hedge's g effect sizes.

findingsMedium-to-large effects (g > 0.5) were observed for increased frontal-plane amputated-limb hip moment and increased sagittal-plane cumulative low back and intact-limb knee moments. Small-to-medium effects (g < 0.5) were observed for improved between-limb frontal-plane hip moment symmetry.

interpretationDespite improved between-limb symmetry, persistent overloading of the intact limb was present one-year after bone-anchored limb implantation. Changes in loading without meaningful changes in average number of daily sit-to-stands suggest potential needs for advanced prosthetic component prescription and more effective movement pattern training for bone-anchored limb users.

Indexed as

Artificial LimbsBone-Anchored ProsthesisFemurJointsAdultAgedAmputation, SurgicalAmputeesBiomechanical PhenomenaFemaleHumansKnee JointMaleMiddle AgedMovementSitting PositionBone-anchored limbBone-anchored prosthesisCumulative loadOsteoarthritisSit-to-standTransfemoral amputation

Identifiers

PMID40037117
PMCPMC11999029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.