ArticleInterdisciplinary cardiovascular and thoracic surgery2025
Subclinical leaflet thrombosis in Ozaki procedure.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Smart Thrombosis Care: The Rise of Closed-Loop Diagnosis-to-Treatment Nano Systems.International journal of nanomedicine · 2025Review
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Authors and funding
4 authors.
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Abstract
Aortic valve reconstruction with autologous glutaraldehyde-fixed pericardium (Ozaki procedure) represents an alternative to conventional prosthetic valve replacement, allowing excellent haemodynamic outcomes. We report two cases of subclinical leaflet thrombosis (SLT) at 12 and 23 months of follow-up. Anticoagulation was initiated, and later echocardiography showed haemodynamic and mobility improvement. SLT is well documented for bioprosthetic valve. To our knowledge, this is the first report for Ozaki procedure in an adult population. Glutaraldehyde is known for cytotoxicity, and partial endothelialization can be responsible for thrombosis, creating favourable conditions for later endocarditis and degeneration. Anticoagulation should be recommended postoperatively for the first 3 months with control at 6 months. Finally, alternative treatment to glutaraldehyde should be investigated.
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