ArticleThe Journal of clinical endocrinology and metabolism2025
Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts.The Journal of clinical endocrinology and metabolism · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
contextWhile increased fiber intake may benefit appetite and metabolism in the general population, its effects in individuals with Prader-Willi syndrome (PWS), a condition characterized by hyperphagia, obesity, and metabolic dysregulation, remain to be explored.
objectiveThis study assessed the effects of a fiber intervention on hyperphagia, metabolic health, and gut microbiota in individuals with PWS, and explored associations between changes in health markers and shifts in microbiota.
methodsParticipants received either a high-dose fiber intervention (35 g/day) or a control for 3 weeks. Following a washout period of 4 to 8 weeks, participants switched treatments for another 3 weeks. Fecal (bacterial 16S ribosomal RNA) and blood (immunometabolic markers, targeted metabolomics) samples were collected before and after each treatment.
resultsFourteen participants (with a median age of 13.6 years, 8 [57.1%] were female) reported high tolerance to the fiber intervention. While it did not significantly alter hyperphagia or key metabolic markers, the fiber intervention led to shifts in gut microbiota diversity and increased the abundance of beneficial bacteria, such as Bifidobacterium longum and Faecalibacterium prausnitzii. Additionally, it altered fecal and serum metabolites, including a decrease in branched-chain fatty acids and an increase in serum C4-OH acylcarnitine.
conclusionWhile this study did not observe significant changes in primary or secondary endpoints, it suggests that a short-term high-fiber intervention may induce beneficial shifts in gut microbiota and microbial metabolites in individuals with PWS. Further research is warranted to investigate the long-term effects and potential therapeutic applications of fiber interventions in PWS.
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