Trial reportSchizophrenia bulletin2025
Potential Delayed Positive Effects of tDCS on Improving Introspective Accuracy in Social Cognition in Schizophrenia.
Trial report in Schizophrenia bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Combining transcranial electrical stimulation with training in older adults: Effects on dual-task ability.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Contextual Engagement to Enhance Effective Transcranial Direct Current Stimulation: A Theoretical and Mechanistic Perspective.Focus (American Psychiatric Publishing) · 2026Article
- Neuromodulation in the treatment of social cognition dysfunction in Schizophrenia: a systematic review.Schizophrenia (Heidelberg, Germany) · 2025Review
- Assessing executive functions and metacognition: translational potential of the Metacognitive Wisconsin Card Sorting Test for developmental neuropsychology.Frontiers in behavioral neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
background and hypothesisImpairments in introspective accuracy (IA) are prominent among schizophrenia patients and detrimentally affect daily functioning, making IA a potential therapeutic target. Recent research highlights the role of the right rostrolateral prefrontal cortex (rlPFC) in IA and suggests that transcranial direct current stimulation (tDCS) to this region may improve it. Therefore, we tested whether applying tDCS to the right rlPFC could enhance IA for schizophrenia patients and explored the potential order/delayed effects. STUDY
designA randomized, double-blind, sham-controlled crossover design was used. Patients with a schizophrenia spectrum disorder (N = 40) underwent 2 tDCS sessions targeting right rlPFC (one was active stimulation and the other was sham) about a week apart. After each session, participants completed executive function and emotion recognition tasks for evaluating IA. STUDY
resultsWhen ignoring order effects, tDCS did not affect performance, IA, or confidence ratings across 3 tasks, except for increased confidence ratings in the cognitive task after active stimulation versus sham. However, considering order effects revealed significant interaction effects between condition and order for both task performance and IA. The group receiving active stimulation at visit 1 (Active First) generally improved over time in both cognitive and social cognitive task performance and in social cognitive IA, specifically for emotion recognition ability. In contrast, the group receiving sham stimulation at visit 1 (Sham First) showed no change in performance or IA over time.
conclusionsOur findings provide preliminary evidence for potential positive, but delayed, effects of tDCS in improving task performance and IA in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.