Evidence map›Paper›PMID 40036847›Full record

ArticleG3 (Bethesda, Md.)2025

A single cell atlas of the mouse seminal vesicle.

Fengyun Sun, Kathleen Desevin, Yu Fu, Shanmathi Parameswaran, Jemma Mayall, Vera Rinaldi, Nils Krietenstein, Artür Manukyan, Qiangzong Yin, Carolina Galan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Fengyun SunDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Kathleen DesevinDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Yu FuDepartment of Systems Biology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.ORCID 0000-0001-6252-3075
Shanmathi ParameswaranHunter Medical Research Institute Infertility and Reproduction Research Program, School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2305, Australia.
Jemma MayallImmune Health Program, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW 2305, Australia.
Vera RinaldiDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.ORCID 0000-0002-0051-1754
Nils KrietensteinDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Artür ManukyanDepartment of Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Qiangzong YinDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Carolina GalanDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Chih-Hsiang YangDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
Anastasia V ShindyapinaDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Manuel GarberDepartment of Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.
John E SchjenkenHunter Medical Research Institute Infertility and Reproduction Research Program, School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, Callaghan, NSW 2305, Australia.ORCID 0000-0001-6293-6160
Oliver J RandoDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, University of Massachusetts, Worcester, MA 01605, USA.ORCID 0000-0003-1516-9397

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
Effects of paternal aging on male reproductive biology and on future generationsR01AG073238 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RANDO, OLIVER J · 2021 to 2025
$2.5M
NIA NIH HHS P01 AG047200NIA NIH HHS R01 AG073238NIH HHS R01AG073238
6 · The paper itself

Abstract

During mammalian reproduction, sperm are delivered to the female reproductive tract bathed in a complex medium known as seminal fluid, which plays key roles in signaling to the female reproductive tract and in nourishing sperm for their onwards journey. Along with minor contributions from the prostate and the epididymis, the majority of seminal fluid is produced by a somewhat understudied organ known as the seminal vesicle. Here, we report the first single-cell RNA-seq atlas of the mouse seminal vesicle, generated using tissues obtained from 23 mice of varying ages, exposed to a range of dietary challenges. We define the transcriptome of the secretory cells in this tissue, identifying a relatively homogeneous population of the epithelial cells which are responsible for producing the majority of seminal fluid. We also define the immune cell populations-including large populations of macrophages, dendritic cells, T cells, and NKT cells-which have the potential to play roles in producing the various immune mediators present in seminal plasma. Together, our data provide a resource for understanding the composition of an understudied reproductive tissue, with potential implications for paternal control of offspring development and metabolism.

Indexed as

Seminal VesiclesSingle-Cell AnalysisTranscriptomeAnimalsGene Expression ProfilingMaleMiceSemenatlaspaternalreproductionseminal vesiclesingle cell

Identifiers

PMID40036847
PMCPMC12060236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.