Trial reportEuropean heart journal. Cardiovascular Imaging2025
Development and validation of a radiomics model for detecting cardiac amyloidosis at coronary computed tomography angiography.
Trial report in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Novel cardiac computed tomography-based preoperative indicator associated with intraoperative graft flow in coronary artery bypass grafting.Journal of thoracic disease · 2026Article
- Analysis of Myocardial Textures in Relation to Nicotine Abuse Using Radiomics in Cardiac PCCT.Tomography (Ann Arbor, Mich.) · 2026Article
- Development and Validation of a Coronary Computed Tomography Angiography-Based Radiomics-Integrated Model for Noninvasive Detection of Left Atrial Appendage Thrombus in Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- CT-based radiomics to predict peri-device leakage after left atrial appendage closure.BMC medical imaging · 2026Article
- An interpretable machine learning approach using nnU-Net-based radiomics for preoperative risk stratification of thymic epithelial tumors: a multicenter study.BMC medical imaging · 2026Article
- Could CT radiomics be the new frontier for myocardial tissue characterization in cardiomyopathies?European heart journal. Cardiovascular Imaging · 2025Article
Corrections and comments
- Commented on by
Authors and funding
19 authors.
Funding
Abstract
aimsTo investigate the diagnostic performance of computed tomography (CT)-based radiomics in detecting cardiac amyloidosis (CA) in patients with diffuse myocardial thickening. METHODS AND
resultsPatients with diffuse myocardial thickening who underwent coronary CT angiography were retrospectively enrolled from five hospitals. Patients from one hospital were randomly divided into training and internal test cohorts at a 7:3 ratio, and the other four hospitals constituted the external test cohort. The diagnosis of CA followed established guidelines. Regions of interest of myocardium were delineated to extract radiomics features to construct the radiomics model, and myocardial CT attenuation was measured. The diagnostic performance and clinical utility of the radiomics model and myocardial CT attenuation were compared with the area under the curve and decision curve analysis. The correlation between radiomics score and left ventricular function was analysed. A total of 378 patients (median age, 57 years; 257 men) were enrolled. Ten features were selected to construct the radiomics model. The areas under the curve of radiomics model were significantly higher than myocardial CT attenuation in the training (0.95 vs. 0.58, P < 0.001), internal test (0.95 vs. 0.59, P < 0.001), and external test cohorts (0.91 vs. 0.64, P < 0.001). Decision curve analysis indicated the radiomics model provided a greater net benefit than myocardial CT attenuation across cohorts. Radiomics scores were correlated with N-terminal proB-type natriuretic peptide and left ventricular diastolic diameter across cohorts (P < 0.05).
conclusionThe radiomics model exhibited good diagnostic performance for CA detection in patients with hypertrophic phenotypes, outperforming myocardial CT attenuation.
Indexed as
Identifiers
40036823What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.