SynthesisOccupational medicine (Oxford, England)2025
Occupational benzene exposure and skin cancers: a systematic review and meta-analysis.
Synthesis in Occupational medicine (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Genomic Impacts of Biological Exposures.Journal of developmental biology · 2026Review
- Pilot study on benzene exposure risks in healthcare workers: a combined socio-demographic and computational toxicology approach.Frontiers in public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to benzene is a widespread occupational hazard that has been associated with haematopoietic neoplasms. The increasing awareness of the health effects that can arise from extended dermal contact with aromatic hydrocarbons, such as benzene, may elevate the risk of skin cancer.
aimsThis study addresses the association between occupational benzene exposure and its incidence and mortality, encompassing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma, as well as cutaneous melanoma (CM).
methodsAfter removing duplicates, we screened 5652 articles from four different sources (Embase, Pubmed, Scopus and IARC Monographs), retrieving 29 independent studies on occupational benzene exposure and skin cancer. The meta-analysis used a random-effects model, overall and stratifying by gender, publication year, outcome, geographic region, industry type and study design.
resultsThe analysis encompasses 18 risk estimates on CM and 21 on either NMSC or not-specified skin cancer (NM/NS) mostly from Europe and North America and predominantly from oil industry cohorts. There was no association with either CM (relative risk [RR] = 0.99, 95% confidence interval [CI] 0.81; 1.21) or NM/NS (RR = 1.19, 95% CI 0.94; 1.50), except for a positive association between employment in the chemical industry and NM/NS risk. There was no evidence of publication bias for either type of cancer (P = 0.70 and P = 0.08).
conclusionsOur meta-analysis found no association between occupational benzene exposure and skin cancer. Further research should aim to describe the association of benzene exposure with skin cancer in less developed countries and among various occupations.
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Registered trials
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