Predicting Escalation of Care for Childhood Pneumonia Using Machine Learning: Retrospective Analysis and Model Development.

Background: Pneumonia is a leading cause of mortality in children aged <5 years. While machine learning (ML) has been applied to pneumonia diagnostics, few studies have focused on predicting the need for escalation of care in pediatric cases. This study aims to develop an ML-based clinical decision support tool for predicting the need for escalation of care in community-acquired pneumonia cases. Objective: The primary objective was to develop a robust predictive tool to help primary care physicians determine where and how a case should be managed. Methods: Data from 437 children with community-acquired pneumonia, collected before the COVID-19 pandemic, were retrospectively analyzed. Pediatricians encoded key clinical features from unstructured medical records based on Integrated Management of Childhood Illness guidelines. After preprocessing with Synthetic Minority Oversampling Technique-Tomek to handle imbalanced data, feature selection was performed using Shapley additive explanations values. The model was optimized through hyperparameter tuning and ensembling. The primary outcome was the level of care severity, defined as the need for referral to a tertiary care unit for intensive care or respiratory support. Results: A total of 437 cases were analyzed, and the optimized models predicted the need for transfer to a higher level of care with an accuracy of 77% to 88%, achieving an area under the receiver operator characteristic curve of 0.88 and an area under the precision-recall curve of 0.96. Shapley additive explanations value analysis identified hypoxia, respiratory distress, age, weight-for-age z score, and complaint duration as the most important clinical predictors independent of laboratory diagnostics. Conclusions: This study demonstrates the feasibility of applying ML techniques to create a prognostic care decision tool for childhood pneumonia. It provides early identification of cases requiring escalation of care by combining foundational clinical skills with data science methods.