ArticleGigaScience2025
Multiomics analysis provides insights into musk secretion in muskrat and musk deer.
Article in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Integrated multi-tissue transcriptomic analysis identifies hub genes associated with egg production recovery after fasting-induced molting.Poultry science · 2026Article
- Deciphering the Link Between Gut Bacterial Community Structure of Forest Musk Deer (Veterinary sciences · 2026Article
- Insights into antibiotic resistomes from gut meta-genome-assembled genomes of the free-range chickens.Veterinary and animal science · 2026Article
- Multi-omics characterization of new and aged Daqu reveals region-specific microbial succession and metabolic signatures in Maotai-flavor liquor fermentation.Microbiology spectrum · 2026Article
- Article
- Role of MEG3-miRNAs in immune-inflammatory regulation in age-dependent wool follicle remodeling in Tan sheep.BMC genomics · 2026Article
- Differential Expression of Hypothalamic Genes in Laying Hens Housed in Caged and Cage-Free Systems Under Commercial Conditions in the Tropics.Animals : an open access journal from MDPI · 2026Article
- Differential analysis of gut microbiota between captive and wild forest musk deer (Frontiers in veterinary science · 2026Article
- Genome-wide identification and expression analysis of Wnt gene family in the forest musk deer (Moschus berezovskii) under musk secretion stage.BMC genomics · 2025Article
- Blood Transcriptome Analysis Reveals Immune Characteristics of Captive Forest Musk Deer (Animals : an open access journal from MDPI · 2025Article
- Transcriptomic profiling of rumen epithelium, liver, and muscle reveals tissue-specific gene expression patterns in Hu sheep.BMC genomics · 2025Article
- Integrated multi-omics reveals the impact of ruminal keystone bacteria and microbial metabolites on average daily gain in Xuzhou cattle.Microbiology spectrum · 2025Article
- Histological and histochemical characterization of the musk gland in forest musk deer (European journal of histochemistry : EJH · 2025Article
- The 3D genome of plasma cells in multiple myeloma.Scientific reports · 2025Article
- Convergent musk biosynthesis across host and microbiota in musk deer and muskrat.Zoological research · 2025Article
- Article
- Volatile Compounds in Musk and Their Anti-Stroke Mechanisms.Metabolites · 2025Article
- Gut Metagenome Reveals the Microbiome Signatures in Tibetan and Black Pigs.Animals : an open access journal from MDPI · 2025Article
- Multiomics analysis provides insights into musk secretion in muskrat and musk deer.GigaScience · 2025Article
- The interplay of carbon and nitrogen cycling driven by watershed microorganisms.Frontiers in microbiology · 2025Review
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Authors and funding
19 authors.
Funding
Abstract
backgroundMusk, secreted by the musk gland of adult male musk-secreting mammals, holds significant pharmaceutical and cosmetic potential. However, understanding the molecular mechanisms of musk secretion remains limited, largely due to the lack of comprehensive multiomics analyses and available platforms for relevant species, such as muskrat (Ondatra zibethicus Linnaeus) and Chinese forest musk deer (Moschus berezovskii Flerov).
resultsWe generated chromosome-level genome assemblies for the 2 species of muskrat (Ondatra zibethicus Linnaeus) and musk deer (Moschus berezovskii Flerov), along with 168 transcriptomes from various muskrat tissues. Comparative analysis with 11 other vertebrate genomes revealed genes and amino acid sites with signs of adaptive convergent evolution, primarily linked to lipid metabolism, cell cycle regulation, protein binding, and immunity. Single-cell RNA sequencing in muskrat musk glands identified increased acinar/glandular epithelial cells during secretion, highlighting the role of lipometabolism in gland development and evolution. Additionally, we developed MuskDB (http://muskdb.cn/home/), a freely accessible multiomics database platform for musk-secreting mammals.
conclusionsThe study concludes that the evolution of musk secretion in muskrats and musk deer is likely driven by lipid metabolism and cell specialization. This underscores the complexity of the musk gland and calls for further investigation into musk secretion-specific genetic variants.
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