Evidence map›Paper›PMID 40036301›Full record

ArticleSchizophrenia bulletin2026

Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders.

Ayesha G Rashidi, Lindsay D Oliver, Iska Moxon-Emre, Colin Hawco, Erin W Dickie, Ruyi Pan, Maria T Secara, Ju-Chi Yu, Peter Szatmari, Pushpal Desarkar and 6 more

Abstract readComparative Study
In one paragraph

Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ayesha G RashidiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.ORCID 0009-0009-5195-0544
Lindsay D OliverCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Iska Moxon-EmreCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Colin HawcoCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Erin W DickieCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Ruyi PanCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Maria T SecaraCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Ju-Chi YuCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Peter SzatmariCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Pushpal DesarkarInstitute of Medical Science, University of Toronto, Toronto, ON M5S 3K3, Canada.
George FoussiasCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Robert W BuchananMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
Anil K MalhotraDivision of Psychiatry Research, Division of Northwell Health, The Zucker Hillside Hospital, Glen Oaks, NY 11004, United States.
Meng-Chuan LaiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Aristotle N VoineskosCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.ORCID 0000-0003-0156-0395
Stephanie H AmeisCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.

Funding

2/3-Social Processes Initiative in Neurobiology of the Schizophrenia(s)R01MH102313 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI MALHOTRA, ANIL K · 2014 to 2018
$1.9M
3/3-Social Processes Initiative in Neurobiology of the Schizophrenia(s)R01MH102318 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI BUCHANAN, ROBERT W, CARPENTER, WILLIAM T. · 2014 to 2018
$1.7M
1/3 - Social Processes Initiative in Neurobiology of the Schizophrenia(s)R01MH102324 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI VOINESKOS, ARISTOTLE NICHOLAS · 2014 to 2018
$1.4M
Social Processes Initiative in Neurobiology of Autism-spectrum and Schizophrenia-spectrum Disorders(SPIN-ASD)R01MH114879 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI AMEIS, STEPHANIE H · 2018 to 2021
$1.1M
NIMH NIH HHS 1/3R01MH102324-01NIMH NIH HHS 2/3R01MH102313-01NIMH NIH HHS 3/3R01MH102318-01NIMH NIH HHS R01 MH102313NIMH NIH HHS R01 MH102318NIMH NIH HHS R01 MH102324NIMH NIH HHS R01 MH114879NIMH NIH HHS R01MH114879
6 · The paper itself

Abstract

background and hypothesisSocial cognitive and neurocognitive performance is impacted in autism and schizophrenia spectrum disorders (SSDs). Here, we compared social cognitive and neurocognitive performance across a large transdiagnostic sample of participants with autism, SSDs, and typically developing controls (TDCs). STUDY

designParticipants (total N = 584; autism N = 100, SSDs N = 275, TDCs N = 209; aged 16-55 years; 61% male assigned at birth) completed lower-level (eg, emotion processing) and higher-level (eg, theory of mind) social cognitive tasks, the MATRICS Consensus Cognitive Battery, and a measure of social functioning. Nonparametric groupwise comparisons were undertaken, adjusting for age and sex, and within-group correlations were used to examine associations between social cognition, neurocognition, and social functioning. STUDY

resultsAutistic and SSD groups performed worse than TDCs on lower- and higher-level social cognitive tasks, with few autism-SSD differences found. Autism and SSDs had lower neurocognitive scores than TDCs; SSDs demonstrated lower processing speed, working memory, verbal learning, and visual learning versus autism. Positive associations between social cognitive tasks and neurocognition were observed across groups, and self-reported measures of empathy were consistently correlated with social functioning.

conclusionsThis study represents the largest transdiagnostic comparison of both social cognition and neurocognition in an autism/SSD sample reported to date. Autistic participants and those with SSDs showed similar performance on lower- and higher-level social cognitive tasks relative to controls, while neurocognition was less impacted in autism versus SSDs. These findings underscore the importance of transdiagnostic research into the mechanisms underlying social cognitive deficits and highlight the potential for developing transdiagnostic interventions.

Indexed as

Autism Spectrum DisorderCognitive DysfunctionSchizophreniaSocial CognitionSocial PerceptionTheory of MindAdolescentAdultFemaleHumansMaleMiddle AgedYoung Adultautism spectrum disorderneurocognitionschizophrenia spectrum disordersocial cognitionsocial functioning

Identifiers

PMID40036301
PMCPMC12809814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.