Evidence map›Paper›PMID 40036292›Full record

ArticlePloS one2025

Expression of cold-inducible RNA-binding protein in mouse spinal cord injury model.

Xinhui Zhang, Yi Zhao, Jing Guo, Jingkun Chen, Xue Gao, Wentao Pan, Hengli Li, Shutong Yao, Yueying Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinhui ZhangThe First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.
Yi ZhaoIntensive Care Medicine Department, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Jing GuoIntensive Care Medicine Department, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Jingkun ChenDepartment of Pathophysiology, School of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xue GaoDepartment of Pathophysiology, School of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Wentao PanDepartment of Pathophysiology, School of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Hengli LiIntensive Care Medicine Department, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Shutong YaoDepartment of Pathophysiology, School of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yueying ZhangThe First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0002-5006-2483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the changes of Cold-Inducible RNA-Binding Protein (CIRBP) expression in mouse spinal cord injury model.

methodsSeventy-five female C57BL/6 mice were randomly divided into five groups, 15 mice per group. According to different degrees of spinal cord injury, they were divided into Mild spinal cord injury, Moderate spinal cord injury, Severe spinal cord injury, Spinal cord amputation group, and Sham surgery group, all constructed with spinal cord percussion. All groups were dissected 1, 3, 5, 14, and 21 days after modeling. HE staining was used to observe the pathological changes in the spinal cord, The Basso mouse scale (BMS) was used for motor function scoring, and immunofluorescence was used to detect the expression of NeuN, IBA-1, and CIRBP in spinal cord tissues.

resultsHE results showed that inflammation was more pronounced in moderate, severe, and amputation injuries compared to the Sham surgery group. Moderate injury group and Severe injury group inflammation increased consistently over time. The severe injury group had severe tissue structure destruction and increased astrocytes significantly. Combined with the mouse BMS motor function score, the mouse severe injury group model was more stable. Compared with the Sham surgery group, there was a significant decrease in NeuN over time (P < 0.01) and a significant increase in IBA-1 and CIRBP (P < 0.01) in the severe injury group. Moreover, IBA-1 has significant co-localization with CIRBP.

conclusionCIRBP expression is significantly elevated in a mouse spinal cord injury model, Which may be related to the proliferation of microglia during spinal cord injury.

Indexed as

RNA-Binding ProteinsSpinal Cord InjuriesAnimalsCalcium-Binding ProteinsDisease Models, AnimalDNA-Binding ProteinsFemaleInflammationMiceMice, Inbred C57BLMicrofilament ProteinsNerve Tissue ProteinsSpinal CordAif1 protein, mouseCalcium-Binding ProteinsCirbp protein, mouseDNA-Binding ProteinsMicrofilament ProteinsNerve Tissue ProteinsNeuN protein, mouseRNA-Binding Proteins

Identifiers

PMID40036292
PMCPMC11878929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.