Evidence map›Paper›PMID 40036010›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2025

Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy.

Hao Yuan, Qun Chen, Kuirong Jiang, Courtney W Houchen, Yuqing Zhang, Min Li

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hao Yuan *Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.ORCID 0009-0007-4848-3354
Qun Chen *Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.ORCID 0000-0002-9034-9825
Kuirong JiangPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0002-2849-5450
Courtney W HouchenDepartment of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.ORCID 0000-0003-2487-5242
Yuqing ZhangDepartment of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.ORCID 0000-0001-8839-4849
Min LiDepartment of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.ORCID 0000-0002-3971-9130

Funding

Prognostic Biomarkers for ZIP4-mediated Cachexia in Pancreatic CancerR01CA203108 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LI, MIN, LI, YI-PING · 2016 to 2020
$2.7M
ZIP4 is a Novel Molecular Target in Human Pancreatic CancerR01CA186338 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FERNANDEZ-ZAPICO, MARTIN ERNESTO, LI, MIN · 2015 to 2019
$1.7M
Role of Zinc Dependent EMT-Transcription Factors (EMT-TF) in Pancreatic Cancer MetastasisR01CA247234 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LI, MIN · 2020 to 2024
$1.6M
NCI NIH HHS R01 CA186338NCI NIH HHS R01 CA203108NCI NIH HHS R01 CA247234William and Ella Owens Medical Research Foundation (William & Ella Owens Medical Research Foundation)
6 · The paper itself

Abstract

The shared HLA-bound neoepitopes in pancreatic ductal adenocarcinoma (PDAC) represent a novel class of noncanonical antigens with single amino acid substitutions resulting from translational errors. These peptides, shared across patients with PDAC, showed higher immunogenicity than wild-type counterparts, offering potential candidates for specific immunotherapy development in PDAC. See related article by Zhang et al., p. 1956.

Indexed as

Antigens, NeoplasmCarcinoma, Pancreatic DuctalEpitopesHLA AntigensImmunotherapyPancreatic NeoplasmsHumansAntigens, NeoplasmEpitopesHLA Antigens

Identifiers

PMID40036010
PMCPMC12081179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.