Evidence map›Paper›PMID 40035982›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2025

Allelic expression imbalance of CDKN2A variants in childhood acute lymphoblastic leukemia.

Zhexuan Tang, Kunlin Pei, Haoyu Xu, Yongzhi Zheng, Shuquan Zhuang, Kaizhi Weng, Yingyi He, Jing Wu, Hui Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhexuan TangFujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Kunlin PeiFujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Haoyu XuDepartment of Paediatrics, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Yongzhi ZhengDepartment of Pediatric Hematology, Fujian Provincial Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.
Shuquan ZhuangDepartment of Paediatrics, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
Kaizhi WengDepartment of Paediatrics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Yingyi HeFujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Jing WuPediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wujingecnu@163.com.
Hui ZhangFujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China. zhang-hui@scmc.com.cn.

Funding

Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province 2022ZQNZD012National Natural Science Foundation of China 82170152Natural Science Foundation of Fujian Province 2023J011313
6 · The paper itself

Abstract

introductionGermline CDKN2A variant predisposes to childhood acute lymphoblastic leukemia (ALL) through allelic expression imbalance (AEI). It is unknown, therefore, how these germline variations work and whether they all confer B-ALL susceptibility through AEI. METHODS AND

resultsUsing allele-specific Taqman PCR assays, we demonstrated that preferentially expressed of those functional inherited coding variants in leukemic cells compared to hematopoietic cells. In an inherent p 16

conclusionThese findings illuminate how inherited CDKN2A genetic variations of coding region influence ALL development through AEI mechanisms.

Indexed as

Cyclin-Dependent Kinase Inhibitor p16Precursor Cell Lymphoblastic Leukemia-LymphomaAllelesAnimalsCell Line, TumorCell Transformation, NeoplasticChildGene Expression Regulation, LeukemicGenetic Predisposition to DiseaseHumansJanus Kinase 2MiceCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Janus Kinase 2Acute lymphoblastic leukemiaAllelic imbalanceCDKN2AInherited coding variantsPredispose

Identifiers

PMID40035982
PMCPMC12119667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.