Evidence map›Paper›PMID 40035978›Full record

ArticleClinical and experimental nephrology2025

Long-term need and potential for withdrawal of enteral feeding in children with chronic kidney disease stage 5D or 5T.

Kei Osaka, Kentaro Nishi, Yuta Inoki, Satoshi Okada, Tomoya Kaneda, Misaki Akiyama, Masao Ogura, Koichi Kamei

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Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kei OsakaDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Kentaro NishiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan. nishi-k@ncchd.go.jp.ORCID http://orcid.org/0000-0002-3436-0392
Yuta InokiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Satoshi OkadaDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Tomoya KanedaDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Misaki AkiyamaDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Masao OguraDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Koichi KameiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with chronic kidney disease (CKD) stage 5 may require long-term enteral tube feeding. However, the factors associated with the need for tube feeding and the potential for its withdrawal are unclear.

methodsThis single-center, retrospective cohort study included patients with CKD stage 5D or 5T aged <18 years between 2004 and 2021. We evaluated data on the initiation of enteral tube feeding and its associated factors, the potential and timing of the withdrawal of enteral tube feeding, and improvements in feeding difficulties before and after kidney transplantation.

resultsOf the 58 study participants, 33 (57%) received enteral tube feeding for more than 1 month. After adjusting for males and major congenital complications, logistic regression analyses identified a younger age at the initiation of kidney replacement therapy as a factor associated with the need for enteral tube feeding (odds ratio: 1.82, 95% confidence interval: 1.28‒2.56, P < 0.001). During the study period, enteral tube feeding was withdrawn from 24 of the 33 (73%) children (withdrawal rates: 2 years, 26%; 3 years, 50%; and 5 years, 66%). Of the nine patients in whom enteral tube feeding was not withdrawn before kidney transplantation, six underwent withdrawal at 0.1, 0.1, 1.1, 1.6, 2.9, and 3.3 years after kidney transplantation, respectively. The remaining three patients continued enteral tube feeding after kidney transplantation.

conclusionsAlthough withdrawal from enteral nutrition is difficult in children with CKD stage 5D or 5T, it may be possible with kidney transplantation or over time.

Indexed as

Enteral NutritionRenal Insufficiency, ChronicWithholding TreatmentAdolescentAge FactorsChildChild, PreschoolFemaleHumansInfantKidney TransplantationMaleRetrospective StudiesTime FactorsEnteral tube feedingKidney failureNutritionPediatricPeritoneal dialysis

Identifiers

PMID40035978

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