Evidence map›Paper›PMID 40035855›Full record

Observational studyJournal of neurology2025

Prevalence of infratentorial superficial siderosis in a large general population sample from the UK Biobank.

N Kharytaniuk, D Hikmat, H Ozkan, E A Lim, D E Bamiou, P Cowley, H R Jäger, D J Werring

Abstract readObservational Study

In one paragraph

Observational study in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N KharytaniukUCL Ear Institute, University College London, 332-336 Gray's Inn Road, London, WC1X 8EE, UK. n.kharytaniuk@ucl.ac.uk.ORCID http://orcid.org/0000-0001-5392-263X

D HikmatStroke Research Centre, Department of Brain Repair and Rehabilitation, Queen Square Institute of Neurology, University College London, London, UK.

H OzkanStroke Research Centre, Department of Brain Repair and Rehabilitation, Queen Square Institute of Neurology, University College London, London, UK.

E A LimLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

D E BamiouUCL Ear Institute, University College London, 332-336 Gray's Inn Road, London, WC1X 8EE, UK.

P CowleyStroke Research Centre, Department of Brain Repair and Rehabilitation, Queen Square Institute of Neurology, University College London, London, UK.

H R JägerStroke Research Centre, Department of Brain Repair and Rehabilitation, Queen Square Institute of Neurology, University College London, London, UK.

D J WerringStroke Research Centre, Department of Brain Repair and Rehabilitation, Queen Square Institute of Neurology, University College London, London, UK.

Funding

University College London Hospitals Biomedical Research Centre BRC-1215-20016-546624

6 · The paper itself

Abstract

backgroundClassical infratentorial superficial siderosis (iSS) is considered a rare but potentially disabling neurological disorder. It results from slow chronic blood extravasation into the cerebrospinal fluid and deposition of the iron degradation product hemosiderin within the subpial layers of the central nervous system. Susceptibility-weighted (SW) magnetic resonance imaging (MRI) is the reference diagnostic modality. Few studies have described the population prevalence of cerebellar or infratentorial siderosis, and there are none from the UK population. The aim of this cross-sectional observational study was to estimate the prevalence of iSS in the UK Biobank sample using pre-defined radiological criteria.

methodsWe reviewed SW MRIs of participants from the UK Biobank, looking for the radiological features of classical iSS: involvement of infratentorial structures (superior vermis, cerebellar folia, brainstem, or craniocervical junction). We calculated the point prevalence as the number of identified cases per total number of cases reviewed and 95% confidence intervals (CI) using Wilson's Score formula.

resultsOf 10,305 SW MRIs reviewed, five cases with radiological features of iSS were identified demonstrating cerebellar/superior vermis involvement. The estimated prevalence of iSS was calculated as 48.5 (95%CI 20.7-113.5) cases per 100,000 population.

conclusionsThis is the first study to estimate iSS prevalence in the UK population. The prevalence of iSS is higher than that reported for other rare neurological and neuro-otological disorders, suggesting an important unmet healthcare need for early diagnosis and targeted management strategies. Further studies are needed to determine the clinical associations and prognostic significance of radiologically defined iSS in the general population.

Indexed as

SiderosisAdultAgedAged, 80 and overBiological Specimen BanksCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrevalenceUK BiobankUnited KingdomInfratentorialPrevalenceSuperficial siderosisUK Biobank

Identifiers

PMID40035855

DOI10.1007/s00415-025-12965-w

PMCPMC11880185

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