Evidence map›Paper›PMID 40035718›Full record

ArticleAnalytical chemistry2025

Electron Transfer Higher-Energy Collisional Dissociation Can Distinguish Cobalt-Adducted Isomers of Human Milk Oligosaccharides.

Darren T Gass, Andrew M Pritchard, Sebastian N Alberti, Elyssia S Gallagher

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Darren T GassDepartment of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, United States.
Andrew M PritchardDepartment of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, United States.
Sebastian N AlbertiDepartment of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, United States.
Elyssia S GallagherDepartment of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, United States.ORCID 0000-0002-5411-7285

Funding

Assessing the Biomolecular Structures that Result from Electrospray IonizationR35GM150464 · NIGMS · BAYLOR UNIVERSITY · PI Elyssia S Gallagher · 2023 to 2026
$1.4M
NIGMS NIH HHS R35 GM150464
6 · The paper itself

Abstract

The ability to identify isomers of human milk oligosaccharides (HMOs) remains a challenge. Typically, HMOs are analyzed using a combination of liquid chromatography and tandem mass spectrometry (LC-MS/MS). Yet, separation methods have been unable to resolve several HMO isomers, necessitating the need for fragmentation methods that can differentiate these structures within mixtures. Common fragmentation methods, such as collision-induced dissociation (CID), often fail to form fragments that can differentiate the linkage and branching isomers. Previously, we determined that electron transfer dissociation (ETD) yields distinct fragmentation products when using certain metal-charge carriers, such as Co

Indexed as

CobaltMilk, HumanOligosaccharidesChromatography, LiquidElectronsElectron TransportHumansIsomerismTandem Mass SpectrometryCobaltOligosaccharides

Identifiers

PMID40035718
PMCPMC12323802

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.