ArticleClinical neuropharmacology
Safety and Outcomes of Valproic Acid in Subarachnoid Hemorrhage Patients: A Retrospective Study.
Matthew J Cobler-Lichter, Kushak Suchdev, Hayley Tatro, Ava Cascone, Joanna Yang, Janice Weinberg, Mohamad K Abdalkader, Hormuzdiyar H Dasenbrock, Charlene J Ong, Anna Cervantes-Arslanian and 4 more
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In one paragraphArticle in Clinical neuropharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors.
Kushak SuchdevDivision of Neurocritical Care, Department of Neurology, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Hayley TatroDepartment of Pharmacy, Boston Medical Center, Boston, MA.
Ava CasconeDepartment of Pharmacy, Boston Medical Center, Boston, MA.
Joanna Yang
Janice WeinbergDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Mohamad K AbdalkaderDepartment of Radiology, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Hormuzdiyar H DasenbrockDepartment of Neurosurgery, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Charlene J Ong
Anna Cervantes-Arslanian
David GreerDivision of Neurocritical Care, Department of Neurology, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Thanh N Nguyen
Ali DaneshmandDivision of Neurocritical Care, Department of Neurology, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
David Y Chung
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MInstitutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7MMultimodal Network Connectivity Architecture (MOCA) of the Brain and its Role in the Recovery of Consciousness in Comatose Cardiac Arrest PatientsR01NS102574 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GREER, DAVID MATTHEW, WU, ONA · 2018 to 2022
$3.4MAddressing an Inherent Bias in Neuroprognostication: A Collaboration Between the US and Brazil to Reduce the Impact of Self-Fulfilling Prophecy in Cardiac ARrEst (SPARE)R01NS128342 · NINDS · BOSTON MEDICAL CENTER · PI David Matthew Greer, Gisele Sampaio Silva · 2024 to 2026
$1.9MBrain Stimulation to Improve Neurocognitive Deficits After Subarachnoid HemorrhageR01NS136224 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI David Young Chung · 2024 to 2026
$1.4MDeterminants of Functional Brain Connectivity After Subarachnoid HemorrhageK08NS112601 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, DAVID YOUNG · 2019 to 2023
$1.0MDynamic Risk Prediction of Life-Threatening Mass Effect After Ischemic StrokeK23NS116033 · NINDS · BOSTON MEDICAL CENTER · PI ONG, CHARLENE J · 2021 to 2025
$1.0MNCATS NIH HHS KL2 TR002542NCATS NIH HHS UL1 TR001430NINDS NIH HHS K08 NS112601NINDS NIH HHS K23 NS116033NINDS NIH HHS R01 NS102574NINDS NIH HHS R01 NS128342NINDS NIH HHS R01 NS136224
6 · The paper itselfAbstract
objectivesAnimal studies have suggested that valproic acid (VPA) is neuroprotective in aneurysmal subarachnoid hemorrhage (SAH). However, the effect of VPA on SAH outcomes in humans has not been investigated.
methodsWe conducted a retrospective analysis of 123 patients with nontraumatic SAH. Eighty-seven patients had an aneurysmal source and 36 patients had no culprit lesion identified. We used stepwise logistic regression to determine the association between VPA and delayed cerebral ischemia (DCI), radiographic vasospasm, and discharge modified Rankin Scale (mRS) score >3.
resultsAll 18 patients who received VPA underwent coil embolization of their aneurysm. VPA use did not have a significant association with DCI on adjusted analysis (odds ratio [OR] = 1.07, 95% confidence interval [CI]: 0.20-5.80). The association between VPA use and vasospasm was OR = 0.64 (0.19-1.98) and discharge mRS > 3 was OR = 0.45 (0.10-1.64). Increased age (OR = 1.04, 1.01-1.07) and Hunt and Hess grade >3 (OR = 14.5, 4.31-48.6) were associated with poor discharge outcome (mRS > 3). Younger age (OR = 0.96, 0.93-0.99), modified Fisher Scale (mFS) score = 4 (OR = 4.14, 1.81-9.45), and Hunt and Hess grade >3 (OR = 2.92, 1.11-7.69) were all associated with development of radiographic vasospasm. There were no complications associated with VPA administration.
conclusionsWe did not observe an association between VPA and the rate of DCI. We found that VPA use was safe in SAH patients who have undergone endovascular treatment of their aneurysm.
Indexed as
Neuroprotective AgentsSubarachnoid HemorrhageValproic AcidAdultAgedBrain IschemiaFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeVasospasm, IntracranialNeuroprotective AgentsValproic Acid
Identifiers
PMID40035592
PMCPMC12843604
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