Evidence map›Paper›PMID 40035550›Full record

ArticleAntimicrobial agents and chemotherapy2025

A microbiological and structural analysis of the interplay between sulbactam/durlobactam and imipenem against penicillin-binding proteins (PBPs) of

Balaji Veeraraghavan, Eunjeong Shin, Yamuna Devi Bakthavatchalam, Abi Manesh, Dilip Dubey, Carlo Tascini, Magdalena A Taracila, Andrea M Hujer, Michael R Jacobs, Robert A Bonomo

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  3. A Clinical Case of Treatment-Emergent Acinetobacter baumannii Non-Susceptibility to Sulbactam-Durlobactam.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  4. Case Commentary: When susceptibility is not enough in recurrentAntimicrobial agents and chemotherapy · 2026
    Article
  5. Article
  6. Sulbactam-Durlobactam for Carbapenem-ResistantPathogens (Basel, Switzerland) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. New Perspectives on Antimicrobial Agents: Sulbactam-durlobactam.Antimicrobial agents and chemotherapy · 2025
    Review
  13. Turning the Tide Against Carbapenem-resistantOpen forum infectious diseases · 2025
    Article
  14. Article
  15. Article
  16. Sulbactam for carbapenem-resistantJAC-antimicrobial resistance · 2025
    Review
  17. Successful Treatment of OXA-23Infection and drug resistance · 2025
    Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Balaji Veeraraghavan *Department of Clinical Microbiology, Christian Medical College, Vellore, India.ORCID 0000-0002-8662-4257
Eunjeong Shin *Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.ORCID 0009-0006-2472-3264
Yamuna Devi BakthavatchalamDepartment of Clinical Microbiology, Christian Medical College, Vellore, India.
Abi ManeshDepartment of Infectious Disease, Christian Medical College and Hospital Vellore, Vellore, India.ORCID 0000-0001-9970-9674
Dilip DubeyInstitute of Critical Care Medicine, Medanta, Lucknow, India.
Carlo TasciniDepartment of Infectious Diseases, University of Udine, Udine, Italy.
Magdalena A TaracilaResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Andrea M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Michael R JacobsDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0002-4235-7855
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the ATTACK Phase 3 trial examining the efficacy of sulbactam (SUL)/durlobactam (DUR) to treat primarily

Indexed as

AcinetobacterAcinetobacter baumanniiAnti-Bacterial AgentsAzabicyclo CompoundsImipenemPenicillin-Binding ProteinsSulbactamAcinetobacter InfectionsBacterial Proteinsbeta-LactamasesDrug SynergismHumansMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-lactamase OXA-23beta-lactamase OXA-51, Acinetobacter baumanniibeta-LactamasescarbapenemasedurlobactamImipenemPenicillin-Binding ProteinsSulbactamATTACK trialbeta-lactamase inhibitordiazabicyclooctanedurlobactamOXA-23PBP1aPBP2PBP3sulbactamsulbactam durlobactam

Identifiers

PMID40035550
PMCPMC11963609

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.