Evidence map›Paper›PMID 40035516›Full record

ArticleJournal of virology2025

HIV-1 single-transcription start-site mutants display complementary replication functions that are restored by reversion.

K Gc, S Lesko, A Emery, C Burnett, K Gopal, S Clark, R Swanstrom, N M Sherer, A Telesnitsky, S Kharytonchyk

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026
    Review
  2. Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

K GcDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
S LeskoMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin, USA.
A EmeryUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
C BurnettDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
K GopalCellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, USA.
S ClarkDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
R SwanstromUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-7777-0773
N M ShererMcArdle Laboratory for Cancer Research, Institute for Molecular Virology, & Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0001-9974-236X
A TelesnitskyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-9878-5931
S KharytonchykDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-7031-8135

Funding

Center for Structural Biology of HIV RNAU54AI170660 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALICE TELESNITSKY · 2022 to 2026
$32.1M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
REGULATION OF TH2 RESPONSES IN ASTHMAP01AI050498 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ZURAW, BRUCE L. · 2001 to 2005
$5.7M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
The Cell Biology of HIV-1 Genome TraffickingR56AI110221 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SHERER, NATHAN M · 2024 to 2024
$457k
NIAID NIH HHS P01 AI050498NIAID NIH HHS R56 AI110221NIAID NIH HHS T32 AI007528NIAID NIH HHS U54 AI170660NIGMS NIH HHS T32 GM145470
6 · The paper itself

Abstract

HIV-1 transcription initiates at two positions, generating RNAs with either

Indexed as

HIV-1MutationRNA, ViralTranscription Initiation SiteViral TranscriptionVirus ReplicationCell LineHIV InfectionsHumansPromoter Regions, GeneticRNA SplicingVirionRNA, ViralHIV-1RNA packagingRNA splicing

Identifiers

PMID40035516
PMCPMC11998490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.