ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
A Tetrazine-Based Synthesis for Accessing Underutilized Aza-Indole Analogues.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Tetrazine-Based Synthesis for Accessing Underutilized Aza-Indole Analogues.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
Aza-indole functionalities fill an important role in drug discovery. While indoles are considered privileged scaffolds, aza-indoles allow for better pharmacological properties and on-target activities. Synthetic approaches to access aza-indoles are limited, with pyrazolopyridazines being some of the scarcest aza-indoles. To provide access to these underutilized cores, a synthetic approach utilizing a reaction cascade between a protected propargylhydrazine and dichlorotetrazine has been developed. In addition, a variety of methods were developed to access each position on the core for late-stage functionalization. This method offers an expedited synthetic route to a rare aza-indole scaffold with superior physiochemical properties when compared to indole analogues.
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